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Pain relief without the risks: World-first discovery of opioid alternative found in Tasmanian mud

<p>Australian scientists think they have found the world’s first alternative to opioid pain relief. </p> <p>The catch? It is in the form of a tiny fungus. </p> <p>The organism was discovered 16 years ago embedded in mud on a boat ramp in Huon Valley, Tasmania. </p> <p>Researchers at the University of Sydney and Queensland University told<span> </span><a rel="noopener" href="https://www.9news.com.au/national/health-news-pain-killing-drugs-alternative-to-opioids-found/7e2e1c11-4895-47b8-b060-86963cef3b69" target="_blank">9News</a><span> </span>they discovered the fungus had an unusual molecule which looked almost identical to endorphins, used as a natural pain relief mechanism. </p> <p>"The molecules we've found hit that opioid receptor just as potent as morphine, but we are very hopeful we have good scientific evidence to believe that they will not have the same adverse side effects," Professor Rob Capon from the University of Queensland said. </p> <p>"No one has ever looked at microorganisms, bacteria and fungi before as a source of pain drugs."</p> <p>One of the dangerous side effects of opioids is that they are able to induce respiratory depression.</p> <p>However researchers are confident this new drug will provide the same pain relief without that risk. </p> <p>"Overdose deaths should decrease dramatically with this drug" Professor Macdonald Christie from the University of Sydney told reporters. </p> <p>"If it's not addictive, then that's even better, because part of the problem is people become addicted to opiates, they use too much, they start to use them illicitly and that's where the problem is."</p> <p>The drug is currently in the discovery phase and scientists are looking for industry partners to take up licenses to their patent. </p> <p>However, it may still be decades before the product hits shelves.</p>

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Deadly brain shrinking fungus found in suburban Australia

<p>A fungus titled as the world’s second deadliest has been discovered in suburban Cairns, with researchers fearing it could be spread throughout the Australian tropics.</p> <p>The Poison Fire Coral fungus has caused multiple deaths throughout Asia and was originally identified by James Cook University’s Dr Matt Barrett after a local photographer took a photo of it growing in Redlynch, a suburb in western Cairns.</p> <p>“Of the hundred or so toxic mushrooms that are known to researchers, this is the only one in which the toxins can be absorbed through the skin,” said Dr Barrett, as he warned people to not touch the fungus.</p> <p>“Just touching the Fire Coral fungus can cause dermatitis (reddening or swelling of the skin). If eaten, it causes a horrifying array of symptoms: initially stomach pain, vomiting, diarrhea, fever and numbness, followed (over hours or days) by delamination of skin on face, hands and feet, and shrinking of the brain, which, in turn, causes altered perception, motion difficulties and speech impediments.”</p> <p>If left untreated, consumption can prove to be fatal due to organ failure and brain nerve damage.</p> <p>The brightly coloured fungus is usually found in the mountains of Japan and Korea, though it has been spotted in Papua New Guinea and Indonesia.</p> <p>Scientists now believe it is naturally growing in Cairns.</p> <p>“This record extends the distribution of the fungus considerably, and it may be even more widespread in tropical Australia,” Dr Barrett warned.</p> <p>“The fact that we can find such a distinctive and medically important fungus like the Poison Fire Coral right in our backyard shows we have much to learn about fungi in northern Australia.”</p>

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