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What is mantle cell lymphoma? Magda Szubanski’s ‘rare and fast-moving’ cancer explained

<div class="theconversation-article-body"><em><a href="https://theconversation.com/institutions/wehi-walter-and-eliza-hall-institute-of-medical-research-822"> </a></em>Beloved Australian actor Magda Szubanski has revealed she’s been diagnosed with a “very rare, very aggressive, very serious” blood cancer called mantle cell lymphoma.</p> <p>In a <a href="https://www.instagram.com/magda_szubanski/reel/DKOM_tZSuO2/">post on social media</a>, Szubanski said she would be starting treatment in a few weeks for the stage 4 cancer, which she called “one of the nasty ones, unfortunately”.</p> <p>So, what is mantle cell lymphoma? And how is it treated?</p> <h2>What is mantle cell lymphoma?</h2> <p>There are more than 100 subtypes of blood cancers, but they are commonly divided into one of two groups. These are <a href="https://medschool.ucla.edu/news-article/leukemia-vs-lymphoma-what-is-the-difference">based on</a> where they originate: leukaemias develop in the bone marrow, and lymphomas develop in the lymphatic system.</p> <p>Lymphomas develop from white blood cells (lymphocytes), which circulate in the blood and lymphatic system and help fight infection.</p> <p>You may not have heard of the <a href="https://cancer.ca/en/cancer-information/what-is-cancer/lymphatic-system">lymphatic system</a>, but it plays a key role in your immune response.</p> <p>The lymphatic circulatory system is responsible for transporting fluids (lymph) around your body. <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/lymph#:%7E:text=Listen%20to%20pronunciation,the%20body%20in%20lymph%20vessels.">Lymph</a> comes from blood plasma, and helps remove waste from your tissues.</p> <p>As part of the lymphatic system, tissues like the spleen and thymus help produce many of the immune cells you use to fight infections.</p> <p>These cells are then housed in specialised organs called lymph nodes – small pea-sized glands located throughout your body.</p> <p>Lymph nodes are kind of like the “war room” of your <a href="https://www.ncbi.nlm.nih.gov/books/NBK279395/">immune</a> <a href="https://www.ncbi.nlm.nih.gov/books/NBK279396/">system</a>.</p> <p>Your body contains hundreds of lymph nodes, and each contains millions of lymphocytes. These include the T and B cells – the main fighting cells in adaptive immunity.</p> <p>If B cells in an area of the lymph node known as the “<a href="https://www.lymphoma.org.au/types-of-lymphoma/non-hodgkin-lymphoma/aggressive-fast-growing-b-cell-nhl/mantle-cell-lymphoma-mcl/">mantle zone</a>” become cancerous, it is called mantle cell lymphoma.</p> <h2>How rare is it?</h2> <p>In 2020, <a href="https://www.aihw.gov.au/reports/cancer/cancer-data-in-australia/contents/blood-cancer-incidence-and-survival-by-histology-e">there were 330 cases</a> of mantle cell lymphoma diagnosed in Australia, accounting for a small fraction (5%) of lymphoma cases.</p> <p>Overall, lymphomas account for around <a href="https://www.canceraustralia.gov.au/cancer-types/lymphoma/lymphoma-australia-statistics">one in twenty</a> new cancer diagnoses. This makes mantle cell lymphoma quite rare.</p> <p>Mantle cell lymphoma is about <a href="https://www.aihw.gov.au/reports/cancer/cancer-data-in-australia/contents/blood-cancer-incidence-and-survival-by-histology-e">three times more common in men than in women</a>, and mostly affects people over the age of 60.</p> <h2>Is there a cure?</h2> <p>Unfortunately, mantle cell lymphoma is largely <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.26523">considered incurable</a> with the therapies currently available.</p> <p>Like many cancers, mantle cell lymphoma can vary in how quickly it develops and its severity.</p> <p>As Szubanski’s cancer has been described as “fast-moving” and is already stage 4, it appears that it is a more serious case.</p> <p>Stage 4 is the most advanced stage – meaning the <a href="https://theconversation.com/how-does-cancer-spread-to-other-parts-of-the-body-219616">cancer has spread</a> (metastasised) to other tissues.</p> <p>Treatment at this stage can be more complicated than when the cancer is caught earlier. But treatment can still help people go on to live for many years.</p> <h2>What does treatment involve?</h2> <p>In her social media post, Szubanski said she will be receiving “one of the best treatments available (the Nordic protocol)”.</p> <p>This is one of the most common treatments for an aggressive lymphoma.</p> <p>The main component is “R-CHOP” – a <a href="https://www.cancer.gov/about-cancer/treatment/drugs/r-chop">combination therapy</a>. It involves a mixture of different drugs, including chemotherapy, to attack the cancer from multiple angles at the same time.</p> <p>Different strengths of the drugs can be used (the maximum strength is sometimes called R-maxi-CHOP).</p> <p>A stem cell transplantation may also be included in the regimen.</p> <p>How effective this treatment is will depend on many different factors, including the type and stage of the lymphoma.</p> <p>The aim is to kill as many cancer cells as possible, and therefore extend a patient’s life for as long as possible.</p> <p>Therapy also focuses on providing a high quality-of-life for patients.</p> <h2>How is it diagnosed?</h2> <p>Szubanski’s mantle cell lymphoma was detected during a breast cancer screen where, <a href="https://www.instagram.com/magda_szubanski/reel/DKOM_tZSuO2/">she says</a>, “they found my lymph nodes were up”.</p> <p>Imaging techniques, such as a mammogram or MRI, may detect tell-tale signs of lymphoma, such as swollen lymph nodes.</p> <p>However a biopsy – <a href="https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/biopsy/art-20043922">a small sample of tissue from the affected area</a> – would then be required to confirm the presence of cancer cells and identify what type.</p> <p>Blood cancer symptoms can be vague, but it’s good to know what to look for.</p> <p>As well as swollen lymph nodes, <a href="https://www.leukaemia.org.au/blood-cancer/blood-cancer-signs-and-symptoms/">symptoms of lymphoma</a> include nausea, tiredness, loss of appetite, fevers, gastrointestinal issues, unexplained weight loss, and night sweats.</p> <p>If you have any concerns, you should consult a doctor.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/257821/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em>By <a href="https://theconversation.com/profiles/john-eddie-la-marca-1503690">John (Eddie) La Marca</a>, Senior Research Officer, Blood Cells and Blood Cancer, <a href="https://theconversation.com/institutions/wehi-walter-and-eliza-hall-institute-of-medical-research-822">WEHI (Walter and Eliza Hall Institute of Medical Research) </a> and <a href="https://theconversation.com/profiles/sarah-diepstraten-1495268">Sarah Diepstraten</a>, Senior Research Officer, Blood Cells and Blood Cancer Division, <a href="https://theconversation.com/institutions/wehi-walter-and-eliza-hall-institute-of-medical-research-822">WEHI (Walter and Eliza Hall Institute of Medical Research) </a></em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-mantle-cell-lymphoma-magda-szubanskis-rare-and-fast-moving-cancer-explained-257821">original article</a>.</em></p> <p><em>Image: ABC / Instagram</em></p> </div>

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Woman’s painful shoulder leads to shock diagnosis

<p dir="ltr">In December 2022, a normal day in the office turned into a nightmare for 24-year-old Kadi Watson.</p> <p dir="ltr">The customer service rep stretched out her hand to feel her shoulder - the same shoulder she'd been experiencing pain with a day prior. </p> <p dir="ltr">Speaking to<em> 7Life</em>, the 24-year-old revealed, “It felt kind of like when you do a workout and then days later you get the muscle soreness.”</p> <p dir="ltr">“I hadn’t done anything to warrant having that soreness.” </p> <p dir="ltr">She said she was feeling between her neck and her right shoulder when she discovered a lump. </p> <p dir="ltr">“OK, that’s a bit unusual,” she recalled. </p> <p dir="ltr">For the next two days, she monitored the lump, but it didn’t go away.</p> <p dir="ltr">So, she booked a doctor’s appointment and her GP reassured her there shouldn’t be “much need to worry”.</p> <p dir="ltr">However, to rule out anything malicious, the GP booked her in for an ultrasound of the lump and an X-ray. </p> <p dir="ltr">A week later, as Watson was set for her ultrasound, the technician contacted a radiologist and requested that Watson also undergo a CT scan. </p> <p dir="ltr">The scan showed “heaps of lumps” around her chest and heart.</p> <p dir="ltr">“That’s when they said, ‘This is more serious than just a lump growing on your neck’,” she revealed.</p> <p dir="ltr">She underwent surgery to remove the lumps and admitted she had come to terms with the possibility she could have cancer. </p> <p dir="ltr">When she learned the results, Watson was diagnosed with Hodgkin Lymphoma - a rare type of blood cancer.</p> <p dir="ltr">“I was expecting a phone call, I knew it wasn’t going to be face to face,” she said, adding that by that point she was exhausted from going to appointments every day and waiting around for calls.</p> <p dir="ltr">“Obviously, a call would have been better, but I got the text message instead,” she explained.</p> <p dir="ltr">“I feel like I was a bit more mentally prepared when I got those results because by that time it had been three or four weeks with, ‘This is what you could have’ and me mentally preparing for that answer.”</p> <p dir="ltr">Watson said her diagnosis put her life into perspective. </p> <p dir="ltr">“I thought by 24 I would have done a bit more than just do the old routine kind of thing,” she said.</p> <p dir="ltr">“I felt like I should have done more with my life than just sat here and worked.</p> <p dir="ltr">“You spend so much time working - and not enough time living.”</p> <p dir="ltr">She has also connected with people on their own journeys throughout 2023 so far.</p> <p dir="ltr">“I get probably five messages a day of people telling me how much this has helped them and what they can look out for,” she admitted.</p> <p dir="ltr">“It’s not really the most common cancer out there and I didn’t know about it until I got diagnosed with it.</p> <p dir="ltr">“So I’m glad to spread a bit more awareness.</p> <p dir="ltr">“I’m very, very excited for the day where I can say ‘I’m in remission’.”</p> <p dir="ltr"><em>Image credit: Instagram</em></p>

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