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Breakthrough study finds genetic link to Parkinson's and ADHD

<p>A major scientific study has found a surprising link between the genes that control brain size and the risk of brain-related conditions. </p> <p>A Queensland Institute of Medical Research Associate Professor Miguel Renteria led an international team of experts who scanned DNA data and MRI scans from 76,000 participants.</p> <p>“Genetic variants associated with larger brain volumes in key brain regions also increase the risk of Parkinson’s disease, while variants linked to smaller brain volumes in key regions are associated with an increased risk of ADHD,” Renteria said. </p> <p>“It brings us closer to answering key questions about how genetics influence brain structure, and how we can potentially treat these conditions in future.”</p> <p>Parkinson’s Australia CEO Olivia Nassaris has celebrated the results of the study, saying the surprising results open the door to future treatment options for Parkinson’s, which currently has no cure or cause.</p> <p>“The more answers we have the closer we are to understanding this condition,” she said.</p> <p>Michael Wiseman, who has been living with Parkinson’s for eight years, said he is pleased more research is being done about the neurodegenerative condition.</p> <p>“I know it’s not going to benefit me in any way, as far as a cure or anything … I just hope they keep going, kicking some goals and finding results because it’s an insidious sort of thing, it’s a passenger I’ll have until I go to the grave.”</p> <p><em>Image credits: Shutterstock </em></p>

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Joel Creasey announces exciting personal news on air

<p>Radio host Joel Creasey has shared the exciting news that he and his partner are now engaged after being together for seven years.</p> <p>Creasey announced the news on his Instagram, also sharing the news with his co-hosts of the <em>Ricki-Lee, Tim and Joel radio show</em> on Nova, recalling how his boyfriend, Jack Stratton-Smith, had surprised him with the proposal on their final night in Monopoli, southern Italy.</p> <p>“Well, you asked what happened on my trip to Italy … I did get engaged to the love of my life after seven and a half years,” Creasey told his co-hosts and listeners on Monday.</p> <p>“He finally popped the question! It was very last-minute, it was the day before we left, actually … It was just on a little rooftop and we had a couple of friends there, and I had no idea. I genuinely had no idea.”</p> <p>He added, “We had many a drink that night and it was very special.”</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/DAiEIlBBnRf/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/DAiEIlBBnRf/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Joel Creasey (@joelcreasey)</a></p> </div> </blockquote> <p>The engagement ring reportedly took a year and a half to make, and was inspired by Creasey's favourite musical Wicked.</p> <p>Creasey explained that the news of his engagement had surprised many people for an unexpected reason.</p> <p>He said, “We’ve been together for ages, a lot of people were like, ‘I thought you were already married!’”</p> <p>Joel and Jack started dating in 2017 after they met at an Adele concert.</p> <p><em>Image credits: Instagram </em></p>

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Billy Connolly shares candid admission about Parkinson's battle

<p>Billy Connolly has shared his candid thoughts around death as he discussed his ongoing battle with Parkinson's. </p> <p>The comedian and actor, 81, recalled how he was told to "confront his illness" after being diagnosed with Parkinson's and prostate cancer on the same day. </p> <p>"You just confront it and make decisions based on it," he told <a href="https://www.mirror.co.uk/3am/celebrity-news/sir-billy-connolly-reveals-first-33564191" target="_blank" rel="noopener"><em>The Mirror</em></a>.</p> <div> <div id="adspot-mobile-mobile-3-above"></div> </div> <p>"You just have to think 'Don't think you are being badly treated [in life] or you have the bad pick of the straws. You are one of millions'."</p> <p>"Then you then realise death is not the big thing everyone has made it out to be. It is nothing. It is just a sudden nothing."</p> <p>Despite the dual diagnosis, Connolly reflected on the "funny week", as he said, "On the Monday, I had hearing aids. On the Tuesday I got pills for heart burn, which I have to take all the time, and on the Wednesday I got news that I had prostate cancer and Parkinson's."</p> <p>The star then joked that he probably got the disease following his several appearances on Michael Parkinson's chat show, saying, "I just thought 'I have got Parkinson's. I wish he (Michael) had kept it to himself!' It was easy (making fun of it)."</p> <p>Earlier this year, Billy issued a health update in which he said being sick feels "strange", telling <em>GB News</em> in February, "Being unwell is strange. Everybody else is OK and you've got this thing that's wrong... you're out of step."</p> <p>Two years ago, ahead of receiving an award, he told <a title="bafta.org" href="https://www.bafta.org/" target="_blank" rel="noopener">Bafta.org</a> he's determined to not let the condition "dictate" who he is and is determined to not let it get him down.</p> <p>"It's really important to work, to draw, to write, to walk silly for your grandchildren," he said at the time.</p> <p>"Doing the same thing you've always done is good for you. I don't let the Parkinson's dictate who I am – I just get on with it. I've had a very successful career and I have no regrets at all."</p> <p><em>Image credits: Joanne Davidson/Shutterstock Editorial </em></p> <p class="mol-para-with-font" style="font-size: 16px; margin: 0px 0px 16px; padding: 0px; min-height: 0px; letter-spacing: -0.16px; font-family: Inter, sans-serif;"> </p>

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Aussie sporting power couple drop huge news

<p>Aussie Swimmer Shayna Jack is engaged! </p> <p>The Olympian, 25, who has just returned from the 2024 Paris Olympics announced that she got engaged to her field hockey player partner Joel Rintala. </p> <p>"We've arrived back on Aus soil with news," she shared on her Instagram stories alongside a ring emoji and photos from their engagement. </p> <p>She then shared a post from their sweet proposal, with the caption: "10•08•2024 ♾️🤵🏽‍♂️Husband to be @joelrintala👰🏼‍♀️Wife to be @shayna_jack"</p> <p>In an update, she shared a reel of her showing off her stunning diamond ring in front of famous monuments and tourist attractions as they travelled around Europe, with the caption: "POV: You got engaged overseas 🤣🫣🥰." </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/C_Fce-WI9tw/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/C_Fce-WI9tw/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Shayna Jack (@shayna_jack)</a></p> </div> </blockquote> <p>Jack's teammates and fans took to the comments to congratulate the Aussie sporting power couple. </p> <p>Her Aussie teammate Ariarne Titmus commented: "Woot woot," with two red heart emojis. </p> <p>"So happy🥰🥰🥰 congratulations to you both!" added swimmer Abbey Harkin. </p> <p>Swimmer Bronte Campbell commented love heart emojis, while Brianna Throssell added: "Sooo happy for you both. Biggest congratulations!"</p> <p>"If anyone deserves to be happy its you ! Congrats," wrote one fan.</p> <p>"Amazing!!!! Huge congrats lovely," added another. </p> <p>The couple are believed to have first started dating back in 2020.</p> <p>It's been a month full of wins for Jack, who took home the gold medals in Paris as part of the 4x100m and 4x200m freestyle teams.</p> <p><em>Images: Instagram</em></p> <p> </p>

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Bondi stabbing survivor recalls terrifying ordeal

<p>Stabbing survivor Liya Barko has recalled the moment she came face-to-face with Joel Cauchi in Bondi Junction Westfield, while also sharing how she is still physically and mentally recovering from the incident. </p> <p>The 35-year-old student and cleaner from Ukraine was one of hundreds of shoppers in Bondi Junction Westfield on April 13th, as she entered the shopping centre to purchase a volleyball. </p> <p>In the middle of her errand, she ran into Joel Cauchi during his stabbing rampage. </p> <p>“I think he just looked at me and he decided in that moment, and then I looked at my hands and I was bleeding,‘ Ms Barko said to <a href="https://www.9news.com.au/national/bondi-junction-stabbing-survivor-recalls-april-13-attack/8ce9d1f2-727a-4767-a23f-886e4e22be84" target="_blank" rel="noopener"><em>9News</em></a>.</p> <p>Cauchi reportedly spoke to Ms Barko after attacking her, with Ms Barko alleging he said “catch you” before continuing his rampage through the centre. </p> <p>Another shopper ran to help Ms Barko following her attack: a man in a green shirt who she is still trying to find and express her thanks. </p> <p>The man dragged Ms Barko to safety inside a store and stemmed the blood flow from her stab wound.</p> <p>"When you are on the floor, you’re bleeding, you can see everyone’s expression and some of them were crying, they were scared … for their lives also,” she said.</p> <p>“I would like to see him again, to at least give him a hug, because I don’t know how we would have managed without him in that moment.”</p> <p>The next thing Ms Barko remembers after being stabbed is waking up in the hospital and seeing the friendly face of her doctor, whose positivity kept her going in difficult times of her healing process. </p> <p>“I just remember (he had a) just so, so open smile and happy face,” she said. “He was so happy, I have never seen someone really so happy."</p> <p>“I thought okay, if I die right now, I’ll just destroy his shift. So I can’t die right now because he’s just so happy.”</p> <p>Like many who were affected by the stabbing, Ms Barko, who has been unable to return to work since the stabbing, still has so many unanswered questions about that fateful day. </p> <p>“My question is how it happened? Why a schizophrenic man was there outside with a knife making a normal Saturday afternoon, he just turn it into hell?”</p> <p>Up to eighteen people were stabbed at Bondi Westfield, with five dead on-site and one woman dying later in hospital. Those killed were Faraz Tahir, 30, Ashlee Good, 38, Jade Young, 47, Dawn Singleton, 25, Pikria Dachria, 55 and Yixuan Cheng, 27.</p> <p><em>Image credits: Nine / Facebook</em></p>

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Kyle Sandilands' family member among first victims stabbed in Bondi

<p>Kyle Sandilands became emotional as he described how his wife’s relative Yvonne Wineberg was one of the first women targeted during the terrifying stabbing <a href="https://www.oversixty.com.au/health/caring/family-of-bondi-killer-break-silence" target="_blank" rel="noopener">attack</a> at Westfield Bondi Junction on Saturday. </p> <p>Speaking to co-host Jackie “O” Henderson and newsreader Brooklyn Ross, on <em>The Kyle &amp; Jackie O show</em> Monday morning, Sandilands revealed: “One of the first women to get stabbed in the shoulder was a family member of ours.</p> <p>“She’s a very close family member to my wife.</p> <p>“So, we were watching it on TV, and saw one of our families were involved and carted off to hospital.”</p> <p>He also said that a Bondi lifeguard, who was trapped in Myer during the incident after the store had pulled down their shutters to keep shoppers safe, had asked to be let out so he could help Wineberg. </p> <p>“He could see our family member that got stabbed laying on the ground. There was so much blood.</p> <p>“He said, ‘if I don’t get to her, she’s losing too much blood’, so they let him out, and he rendered assistance before the paramedics arrived.”</p> <p>Sandilands didn't name the lifeguard, but shared the horrors the lifeguard witnessed during the attack. </p> <p>“He said every 50 foot there was another person laying in a pile of blood — all the way down the mall,” the KIIS FM star said. </p> <p>Wineberg was released from hospital on Sunday afternoon.</p> <p>NSW Police identified Joel Cauchi as the killer on Sunday.</p> <p>He was fatally shot just minutes after he left six dead and 12 injured during the terrifying attack at the shopping centre on Saturday night. </p> <p>Cauchi's parents have <a href="https://www.oversixty.com.au/health/caring/family-of-bondi-killer-break-silence" target="_blank" rel="noopener">spoken out</a> and expressed their devastation and disbelief at their son's actions, describing the attack as "truly horrific".</p> <p>They also said that they "have no issues with the police officer who shot our son as she was only doing her job to protect others and we hope she is coping alright.”</p> <p>Cauchi's victims included Pikria Darchia, 55, Ashlee Good, 38;  Faraz Tahir, 30; Dawn Singleton, 25; Jade Young, 47; and Yixuan Cheng, 25.</p> <p>A dozen others – mostly women – were also injured, including Good’s nine-month old baby girl. </p> <p><em>Images: 7NEWS</em></p> <p> </p>

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Family of Bondi killer break silence

<p>The devastating events that unfolded at Westfield Bondi Junction have left a community in shock and mourning, grappling with the aftermath of a senseless act of violence.</p> <p>Joel Cauchi's frenzied stabbing attack claimed the lives of six innocent people, leaving many others injured and traumatised. Now, amidst the grief and confusion, Cauchi's family has stepped forward to offer their perspective on the tragic incident.</p> <p>In a statement conveyed through Queensland police, Andrew and Michele Cauchi, parents of the assailant, expressed profound sorrow and disbelief at their son's actions, describing the events as "truly horrific".</p> <p>“We are absolutely devastated by the traumatic events that occurred in Sydney yesterday,” they said. “Our thoughts and prayers are with the families and friends of the victims and those still undergoing treatment at this time.</p> <p>“Joel’s actions were truly horrific and we are still trying to comprehend what has happened. He has battled with mental health issues since he was a teenager.</p> <p>“We are in contact with both the NSW Police Force and Queensland Police Service and have no issues with the police officer who shot our son as she was only doing her job to protect others and we hope she is coping alright.”</p> <p>Assistant Commissioner Roger Lowe of the Queensland Police provided additional insights into Joel's circumstances leading up to the attack. He disclosed that Joel had been diagnosed with schizophrenia at the age of 17 and had received treatment for mental health issues in the past. However, in recent years, his condition had worsened, casting a shadow over his family's attempts to understand and support him.</p> <p>The revelation that Joel had been sleeping in a vehicle or at a backpacker hostel prior to the attack underscores the challenges faced by individuals grappling with mental illness and homelessness. Despite sporadic communication with his family, Joel's isolation and distress seemed to have deepened in the days preceding the tragic incident.</p> <p>In the wake of the attack, the Cauchi family exhibited a remarkable level of cooperation with law enforcement agencies, expressing concern for the welfare of Inspector Amy Scott, who was compelled to use lethal force against Joel Cauchi. Their willingness to engage with authorities and convey their condolences to the victims' families highlights their recognition of the gravity of the situation and their desire for understanding and healing amidst the tragedy as the community mourns this unbearable loss<span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">.</span></p> <p>Cauchi' victims included Pikria Darchia, a 55-year-old artist and designer; osteopath Ashlee Good, 38; security guard Faraz Tahir, 30; Dawn Singleton, 25 – the daughter of Australian multi-millionaire advertising guru John Singleton; architect Jade Young, 47; and student Yixuan Cheng, 25. A dozen others – mostly women – were also injured, including Good’s infant child.</p> <p><em>Images: Nine News</em></p>

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3 cholesterol myths debunked

<p>For years, cholesterol has been seen as the villain in your diet – responsible for many of the health woes people experience daily. But many of the “facts” about cholesterol are actually just misconceptions. So let’s clear up some of these myths now.</p> <p>As with everything to do with your diet, any major changes should be made in consultation with your healthcare professional or a nutritionist to make sure it’s right for you.</p> <p><strong>Cholesterol is bad for you</strong></p> <p>Just like cake, cholesterol should be enjoyed in moderation. Interestingly, it actually performs many important functions. It helps produce cell membranes, vitamin D, hormones, and helps with digestion. It also plays a role in helping to form memories.</p> <p>And, believe it or not, cholesterol is naturally created by your body. So most of the cholesterol in your bloodstream is not there because of your diet.</p> <p><strong>Eggs are the enemy</strong></p> <p>People with high cholesterol levels used to be advised to avoid eating too many eggs, but they’ve recently been put back on the “safe list.” Research at Yale University actually showed that even people with coronary heart disease could eat two eggs each day for six weeks without any effect on their cholesterol levels.</p> <p><strong>Low-fat diets are the best</strong></p> <p>While saturated fats do increase the “bad” cholesterol (LDL), it also increases the levels of “good” cholesterol (HDL). A study published in Annals of Internal Medicine showed no link between the consumption of saturated fats and an increased risk of heart attacks.</p> <p>Foods that are high or low in saturated fat can have a positive, negative, or neutral effect on your body – it all depends on the type of food. A diet that is low in carbohydrates is more effective at raising the levels of “good” cholesterol in your system.</p> <p><em>Image credits: Getty Images </em></p>

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Kerri-Anne’s emotional tribute to her late husband and dear friend

<p dir="ltr">Kerri-Anne Kennerley has shared an emotional tribute to her late husband John on their 39th wedding anniversary. </p> <p dir="ltr">The former TV host posted a rare glimpse into her wedding day, as the newlyweds smiled alongside their friend Michael Parkinson, who recently passed away. </p> <p dir="ltr">“Today would have been John and my 39th Wedding anniversary,” she began in the tribute post. </p> <p dir="ltr">She then went on to acknowledge the death of her friend, who died on August 16th after a short battle with an illness. </p> <p dir="ltr">“It is also a day to celebrate Sir Michael Parkinson. It was a privilege to know him as a friend and someone professionally who was a huge inspiration,” she wrote.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/p/CwEO6CYScCb/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CwEO6CYScCb/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Kak 💁🏼‍♀️ (@kerriannekennerley)</a></p> </div> </blockquote> <p dir="ltr">“I will never forget those two weeks on <em>Good Morning Australia</em> with Michael, an absolute masterclass,” she added. </p> <p dir="ltr">Kerri-Anne’s husband John passed away in February 2019 after he suffered a fall from a balcony in 2016 that left him partially paralysed.</p> <p dir="ltr">In September 2022, Kerri-Anne spoke about her grief to <em><a href="https://www.dailymail.co.uk/tvshowbiz/article-12425509/Kerri-Anne-Kennerley-shares-heartbreaking-tribute-late-husband-John-39th-wedding-anniversary-death-friend-Michael-Parkinson.html" target="_blank" rel="noopener">Daily Mail Australia</a></em>, admitting she misses everything about her longtime love.</p> <p dir="ltr">“You know, the little things, the big things. There's not a day... But as the years go by, I think it is ever so slightly easier. [But it] doesn't make it any less lonely,” she says.</p> <p dir="ltr">While she wouldn't say if a future romance was on the cards, Kerri-Anne says she has a great support network to help her combat the waves of loneliness and grief.</p> <p dir="ltr">“I've got lots of fab friends and family. I'm very, very close to my sister and brother in law,” she explains, adding she recently returned from her first overseas trip in three years.</p> <p dir="ltr">“I have sensational friends who are very attentive and include me in lots of stuff, as does family.”</p> <p dir="ltr"><em>Image credits: Instagram</em></p>

Family & Pets

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Paul McCartney’s unusual relationship with Michael Parkinson

<p>Paul McCartney has paid tribute to Michael Parkinson, calling him a “great guy” and a “good friend” in a lengthy and heartfelt post on social media.</p> <p>The iconic interviewer passed away peacefully at home on August 16th after a battle with a brief illness according to a statement from his family.</p> <p>After his death, a flood of tributes poured in from celebrities around the world, including The Beatles frontman Paul McCartney.</p> <p>Parkinson was a personal friend of McCartney’s, as the pair even appeared on a famous album cover together.</p> <blockquote class="twitter-tweet"> <p>I first met Michael Parkinson in Liverpool when he and his team came to see us at the Cavern Club. He was a very likeable guy and we eventually did our first TV performances with Granada in Manchester, where Michael worked.</p> <p>Through the years I got to know him more and more, and… <a href="https://t.co/o0fMiXsWwN">pic.twitter.com/o0fMiXsWwN</a></p> <p>— Paul McCartney (@PaulMcCartney) <a href="https://twitter.com/PaulMcCartney/status/1692969489980063890?ref_src=twsrc%5Etfw">August 19, 2023</a></p></blockquote> <p>The two feature on the album cover of Wings‘ coveted "<em>Band On The Run</em>" record as escaped convicts, with Parkinson agreeing to appear on the cover if McCartney would return the favour by being a guest on his chat show.</p> <p>Taking to Twitter on Saturday, McCartney remembered his friend, writing, “I first met Michael Parkinson in Liverpool when he and his team came to see us at the Cavern Club. He was a very likeable guy and we eventually did our first TV performances with Granada in Manchester, where Michael worked.”</p> <p>“Through the years I got to know him more and more, and appeared on his chat show quite a few times. He was a pleasure to talk to and we always had fun. He appeared on the front cover of ‘<em>Band on the Run</em>’ as one of the escaping convicts in the title song. He was very knowledgeable about many subjects and a keen sports-lover.”</p> <p>He added, “I will miss him personally, as a good friend. I send all my love to his family and friends. Cheers Michael, you’re a great guy okay!”</p> <p><em>Image credits: Paul McCartney / Twitter (X)</em></p>

Music

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"One of the greats": Elton John's stirring tribute to Michael Parkinson

<p>The entertainment world has been cast into a somber veil of mourning as it bids farewell to the iconic Michael Parkinson, the legendary interviewer who has left us at the age of 88.</p> <p>Elton John, David Attenborough, Michael Caine, Eric Idle ...the long list of luminaries who have joined the chorus of heartfelt tributes to the "TV titan" and the undisputed "king of the chat show" seems limitless.</p> <p>The poignant words of Oscar-winning Michael Caine resonate with a sense of irreparable loss: “Michael Parkinson was irreplaceable," he wrote. "He was charming, always wanted to have a good laugh. He brought the best of everyone he met. Always looked forward to be interviewed by him.”</p> <p>David Attenborough's reflection on his interactions with the man affectionately known as "Parky" evokes a sense of melancholic nostalgia: “He was extremely generous, he wanted you to shine and would always laugh at your jokes and give you an opportunity to make them sound funnier than in fact they were. It was always friendly, it was always thorough, it was always intelligent, it was always a pleasure to do it and I think that came over no matter who his interviewee was.”</p> <p>Elton John said Parkinson was “a TV legend who was one of the greats. I loved his company and his incredible knowledge of cricket and Barnsley Football Club. A real icon who brought out the very best in his guests. Condolences and love to Mary and his family."</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CwC4JoBMmKq/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CwC4JoBMmKq/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Elton John (@eltonjohn)</a></p> </div> </blockquote> <p>The reminiscences continue, with Stephen Fry's words dripping with a bittersweet tone, saying that being interviewed by Parkinson was an experience of impossibly intense thrill.</p> <p>“The genius of Parky was that (unlike most people (and most of his guests, me included) he was always 100 per cent himself. On camera and off. ‘Authentic’ is the word I suppose,” he wrote. “For one of the shows I was on with Robin Williams, a genius of unimaginable comic speed and brilliance. Now they’re both gone.</p> <p>“One should get used to the parade of people constantly falling off the edge, but frankly one doesn’t. So long #parky.”</p> <p>The poignant announcement of the loss came from Parkinson's family. “After a brief illness Sir Michael Parkinson passed away peacefully at home last night in the company of his family,” the statement read.</p> <p>“The family request that they are given privacy and time to grieve.”</p> <p>The memories flood in as the recollection of Parkinson's rise to prominence in the 1970s fills the air with a sense of wistfulness. His list of more than 2000 interviewees includes luminaries such as Sir Billy Connolly, Muhammad Ali, Prince Philip, Sir Elton John, Madonna, and Paul McCartney.</p> <p>Four-time guest Muhammad Ali's absence echoes through time as Parkinson's voice emerges: “When people ask me who I most enjoyed interviewing, I’m unable to give them an answer”, Parkinson once said in an interview. “If they ask me who was the most remarkable man I ever met, I answer without hesitation – Muhammad Ali. I interviewed him four times – I lost on every occasion.”</p> <p>These titanic verbal sparring matches stand as poignant testimonies of the show's indelible legacy, underscoring their magnetic effect on millions of viewers.</p> <p>Among the program's other poignant moments, the chaos induced by Rod Hull's puppet Emu assaulting Parkinson on his own talk show couch remains etched in memory. Parkinson jestingly admitted that his career would forever be epitomised by "that bloody bird".</p> <p><em>Images: Getty / BBC 1</em></p>

Caring

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How Richard Wilkins impressed Michael Parkinson

<p>Richard Wilkins has opened up on his memorable interview with media legend Michael Parkinson, and how he managed to impress the interview king with one simple question. </p> <p>From a young age, Wilkins was in awe of Parkinson's interviewing ability, watching his every show with his parents during his childhood. </p> <p>Over the course of his astonishing career, Parkinson, a broadcast journalist and author, had interviewed more than 2,000 people. </p> <p>An inspiration to Dickie, the Nine journalist admitted that "in a weird way" watching the media icon propelled him to want to get up close and personal with some of those people as well.</p> <p>When Wilkins got the chance to sit down with Parkinson in 2019, he said the two just "clicked", making it one of his most memorable interviews.</p> <p>"I guess the older type people, who I've grown up appreciating what they do, I think they get a sense that you're not necessarily a fawning fan, but you certainly know what you're talking about and are up for a chat," Wilkins told <a href="https://celebrity.nine.com.au/latest/richard-wilkins-interview-michael-parkinson-dickies-diaries-exclusive/f7fde9cc-49bd-4dcb-a742-5ab8f0f9d563" target="_blank" rel="noopener"><em>9Honey Celebrity</em></a>.</p> <p>During their conversation, Wilkins impressed Parkinson with a question he had never been asked before. </p> <p>"I said, 'So, how important is that first question when you're sitting down opposite someone and you're trying to break the ice and get into their heads?' Wilkins recalled.</p> <p>"I've never been asked that before," Parkinson, then 85-year-old, said.</p> <p>"He said 'Well, it's very important, and I always think very long and hard about the first question.'"</p> <p>"And I said, 'So, how was that one?' He said, 'It was very good'. So we got on very well."</p> <p>At the end of their chat, Parkinson shared some wisdom with Wilkins, which he carries with him throughout his work. </p> <p>Parkinson said, "I think the most important thing about interviewing is to actually establish a relationship with the person sitting opposite because after all, it's a totally phoney operation."</p> <p>"All this nonsense, around, this palava, walking down the stairs, the band playing, all that sort of stuff. And I don't care who you are, when you reach the bottom of the stairs, you see this stranger opposite you, me, and you think 'what the hell am I doing here'."</p> <p><em>Image credits: Nine</em></p>

TV

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Billy Joel lists New York estate for $73 million

<p>Legendary rocker Billy Joel is <a href="https://www.oversixty.com.au/entertainment/music/billy-joel-in-tears-over-career-announcement" target="_blank" rel="noopener">saying goodbye to The Big Apple</a> as he prepares to sell his jaw-dropping estate.</p> <p>The New York native’s property on the affluent Oyster Bay Harbour has a price guide of a staggering US$49 million (AU$73.4 million).</p> <p>According to the Wall Street Journal, the 26-acre estate comprises the original 14-acre property Joel bought for $22.5 million in 2002 and the adjoining area he’s purchased over the years.</p> <p>The property covers more than 600m of frontage on Centre Island, with the focal point of the estate being the 1,858 sqm main house with breathtaking water views.</p> <p>The home includes five bedrooms, six bathrooms, two half-baths, a playroom, a spa and hair salon, a bowling alley, and a wine centre.</p> <p>There is also an indoor pool, which the Piano Man singer has covered up to use as a music room as it offers fantastic acoustics, according to listing agent Bonnie Williamson, of Daniel Gale Sotheby’s International Realty.</p> <p>Parts of the main house are under renovation and are expected to be finished over the next several months.</p> <p>The magnificent estate also has a three-bedroom beach house, a three-bedroom guest apartment, and a four-bedroom gatehouse.</p> <p>Other amenities include a floating dock and boat ramp, two outdoor pools, and a helicopter pad.</p> <p><em>Image credit: Getty / Realestate.com.au</em></p>

Real Estate

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Billy Joel in tears over career announcement

<p>American singer and ‘Piano Man’ Billy Joel is set to conclude his “extraordinary” Madison Square Garden residency with his 150th lifetime show. </p> <p>Joel, MSG CEO James Dolan, and New York City Mayor Eric Adams were at a press conference at the venue when the announcement was made, with Dolan taking to the stage to share that the first of the star’s final ten concert will take place in October 2023, with the final one scheduled for July 2024. </p> <p>"What Billy Joel has accomplished is extraordinary," Dolan said. "Although the residency is coming to an end, we look forward to an exciting closing run to celebrate all that you have accomplished and forever welcoming you back home to the garden anytime, anytime you like."</p> <p>An MSG Entertainment representative went on to discuss Joel’s time at the venue - with the singer having headlined over 60 times more than any other artist, and having sold more than 1.6 million tickets - before a video tribute was played in his honour, prompting another round of tears from him.</p> <p>In the wake of the announcement, Joel went on to offer his own words, telling the crowd, “Madison Square Garden is more than just our office, it's our home.</p> <p>"I'm kinda flabbergasted it lasted as long as it did.</p> <p>"It's hard to end – even 150 lifetime shows, but as I said, we're not abandoning New York, we're just spending a bit more time someplace else.”</p> <p>Reportedly, Joel’s team had advised him that the show could have gone on, but he had reached the decision that it was time to bring it to a close. </p> <p>“It keeps selling, people keep coming, people keep buying tickets,” he said, “[but] I'm now 74, seems like a nice number to just [say] 'okay'.”</p> <p>And as Mayor Adams went on to share, Joel’s music wasn’t going anywhere, even if the residency was moving on. </p> <p>"There's only one thing that's more New York than Billy Joel – and that's a Billy Joel concert at MSG," he said. "For more than 50 years, Billy's music has defined our city and brought us together. </p> <p>“On behalf of 8.5 million New Yorkers, congratulations, Billy, on a historic run of sold-out shows at MSG, and thank you for a lifetime of bringing joy to us all."</p> <p>When the news broke on social media, fans were sad to know the performances would be over, but wasted no time in congratulating him for a job well done, and thanking him for sharing his music with the world. </p> <p>“All good things must come to a end,” one wrote, “congratulations on this amazing run and thank you for some special memories”.</p> <p>“OMG I hope to see one of your shows by then,” another shared. “You give great concerts. That final performance there will be such a heartfelt sadness for all your fans who just love hearing and seeing you perform. Billy Joel, you are amazing and loved.”</p> <p>And as one other told the beloved Piano Man, “incredible! Congratulations and thank you for sharing your beautiful creativity with us. You've entertained, soothed and made us think. All the best!!”</p> <p><em>Images: Getty</em></p>

Music

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Chelsea buns

<p>This plump, fruit-filled bun has been around since the 18th century, and there’s a reason it remains popular to this day. Try our cranberry version of this English institution.</p> <p><strong><span style="text-decoration: underline;">Ingredients:</span></strong></p> <ul> <li>¾ cup warm milk</li> <li>14g dry yeast</li> <li>¼ cup caster sugar</li> <li>3 ½ cups plain flour</li> <li>1 teaspoon salt</li> <li>60g butter, chopped</li> <li>2 eggs, lightly beaten</li> <li>1 ½ cups dried cranberries</li> <li>⅓ cup brown sugar</li> <li>1 ½ teaspoons cinnamon</li> <li>1 orange rind, finely grated</li> <li>70g butter, softened</li> </ul> <p><strong><span style="text-decoration: underline;">Method:</span></strong></p> <ol> <li>Whisk together the milk, yeast, and two teaspoons of the caster sugar. Leave aside in a warm place for about 10 minutes, until frothy.</li> <li>Into a large bowl, sift the flour then stir in the salt and remaining caster sugar.</li> <li>Use your fingertips to rub the chopped butter into the flour mixture until it resembles fine breadcrumbs.</li> <li>Add the milk mixture and eggs and stir until combined. Turn the dough onto a lightly floured surface and knead until smooth (around 10 minutes).</li> <li>Place the dough into a greased bowl, cover with plastic wrap, and set aside in a warm place for at least 40 minutes, or until doubled in size.</li> <li>Turn the dough onto a lightly floured surface and roll it out into a rectangle of about 30cm by 35cm. Set aside two teaspoons of the softened butter and spread the rest over the dough.</li> <li>In a bowl, combine the cranberries brown sugar, cinnamon, and orange rind. Spread this mixture evenly over the buttered dough.</li> <li>Roll the dough from the longer side. Cut into three-cm-thick slices and place into a greased a 20 to 25cm cake tin or baking dish. Be sure to leave a little room between each bun. Set the buns aside for about 20 minutes to rise.</li> <li>Preheat your oven to 200°C and spread the remaining softened butter over the buns.</li> <li>Bake buns for two to 25 minutes, or until they’re golden brown and cooked through. Allow to cool in the pan for 10 minutes before moving to a wire rack to cool completely.</li> </ol> <p><em>Images: Shutterstock</em></p>

Food & Wine

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Here’s how a new AI tool may predict early signs of Parkinson’s disease

<p>In 1991, the world was shocked to learn actor <a href="https://www.theguardian.com/film/2023/jan/31/still-a-michael-j-fox-movie-parkinsons-back-to-the-future">Michael J. Fox</a> had been diagnosed with Parkinson’s disease. </p> <p>He was just 29 years old and at the height of Hollywood fame, a year after the release of the blockbuster <em>Back to the Future III</em>. This week, documentary <em><a href="https://www.imdb.com/title/tt19853258/">Still: A Michael J. Fox Movie</a></em> will be released. It features interviews with Fox, his friends, family and experts. </p> <p>Parkinson’s is a debilitating neurological disease characterised by <a href="https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055">motor symptoms</a> including slow movement, body tremors, muscle stiffness, and reduced balance. Fox has already <a href="https://www.cbsnews.com/video/michael-j-fox-on-parkinsons-and-maintaining-optimism">broken</a> his arms, elbows, face and hand from multiple falls. </p> <p>It is not genetic, has no specific test and cannot be accurately diagnosed before motor symptoms appear. Its cause is still <a href="https://www.apdaparkinson.org/what-is-parkinsons/causes/">unknown</a>, although Fox is among those who thinks <a href="https://www.cbsnews.com/video/michael-j-fox-on-parkinsons-and-maintaining-optimism">chemical exposure may play a central role</a>, speculating that “genetics loads the gun and environment pulls the trigger”.</p> <p>In research published today in <a href="https://pubs.acs.org/doi/10.1021/acscentsci.2c01468">ACS Central Science</a>, we built an artificial intelligence (AI) tool that can predict Parkinson’s disease with up to 96% accuracy and up to 15 years before a clinical diagnosis based on the analysis of chemicals in blood. </p> <p>While this AI tool showed promise for accurate early diagnosis, it also revealed chemicals that were strongly linked to a correct prediction.</p> <h2>More common than ever</h2> <p>Parkinson’s is the world’s <a href="https://www.who.int/news-room/fact-sheets/detail/parkinson-disease">fastest growing neurological disease</a> with <a href="https://shakeitup.org.au/understanding-parkinsons/">38 Australians</a>diagnosed every day.</p> <p>For people over 50, the chance of developing Parkinson’s is <a href="https://www.parkinsonsact.org.au/statistics-about-parkinsons/">higher than many cancers</a> including breast, colorectal, ovarian and pancreatic cancer.</p> <p>Symptoms such as <a href="https://www.apdaparkinson.org/what-is-parkinsons/symptoms/#nonmotor">depression, loss of smell and sleep problems</a> can predate clinical movement or cognitive symptoms by decades. </p> <p>However, the prevalence of such symptoms in many other medical conditions means early signs of Parkinson’s disease can be overlooked and the condition may be mismanaged, contributing to increased hospitalisation rates and ineffective treatment strategies.</p> <h2>Our research</h2> <p>At UNSW we collaborated with experts from Boston University to build an AI tool that can analyse mass spectrometry datasets (a <a href="https://www.sciencedirect.com/topics/neuroscience/mass-spectrometry">technique</a> that detects chemicals) from blood samples.</p> <p>For this study, we looked at the Spanish <a href="https://epic.iarc.fr/">European Prospective Investigation into Cancer and Nutrition</a> (EPIC) study which involved over 41,000 participants. About 90 of them developed Parkinson’s within 15 years. </p> <p>To train the AI model we used a <a href="https://www.nature.com/articles/s41531-021-00216-4">subset of data</a> consisting of a random selection of 39 participants who later developed Parkinson’s. They were matched to 39 control participants who did not. The AI tool was given blood data from participants, all of whom were healthy at the time of blood donation. This meant the blood could provide early signs of the disease. </p> <p>Drawing on blood data from the EPIC study, the AI tool was then used to conduct 100 “experiments” and we assessed the accuracy of 100 different models for predicting Parkinson’s. </p> <p>Overall, AI could detect Parkinson’s disease with up to 96% accuracy. The AI tool was also used to help us identify which chemicals or metabolites were likely linked to those who later developed the disease.</p> <h2>Key metabolites</h2> <p>Metabolites are chemicals produced or used as the body digests and breaks down things like food, drugs, and other substances from environmental exposure. </p> <p>Our bodies can contain thousands of metabolites and their concentrations can differ significantly between healthy people and those affected by disease.</p> <p>Our research identified a chemical, likely a triterpenoid, as a key metabolite that could prevent Parkinson’s disease. It was found the abundance of triterpenoid was lower in the blood of those who developed Parkinson’s compared to those who did not.</p> <p>Triterpenoids are known <a href="https://www.sciencedirect.com/topics/neuroscience/neuroprotection">neuroprotectants</a> that can regulate <a href="https://onlinelibrary.wiley.com/doi/10.1002/ana.10483">oxidative stress</a> – a leading factor implicated in Parkinson’s disease – and prevent cell death in the brain. Many foods such as <a href="https://link.springer.com/article/10.1007/s11101-012-9241-9#Sec3">apples and tomatoes</a> are rich sources of triterpenoids.</p> <p>A synthetic chemical (a <a href="https://www.cdc.gov/biomonitoring/PFAS_FactSheet.html">polyfluorinated alkyl substance</a>) was also linked as something that might increase the risk of the disease. This chemical was found in higher abundances in those who later developed Parkinson’s. </p> <p>More research using different methods and looking at larger populations is needed to further validate these results.</p> <h2>A high financial and personal burden</h2> <p>Every year in Australia, the average person with Parkinson’s spends over <a href="https://www.hindawi.com/journals/pd/2017/5932675/">A$14,000</a>in out-of-pocket medical costs.</p> <p>The burden of living with the disease can be intolerable.</p> <p>Fox acknowledges the disease can be a “nightmare” and a “living hell”, but he has also found that “<a href="https://www.cbsnews.com/video/michael-j-fox-on-parkinsons-and-maintaining-optimism">with gratitude, optimism is sustainable</a>”. </p> <p>As researchers, we find hope in the potential use of AI technologies to improve patient quality of life and reduce health-care costs by accurately detecting diseases early.</p> <p>We are excited for the research community to try our AI tool, which is <a href="https://github.com/CRANK-MS/CRANK-MS">publicly available</a>.</p> <p><em>This research was performed with Mr Chonghua Xue and A/Prof Vijaya Kolachalama (Boston University).</em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/heres-how-a-new-ai-tool-may-predict-early-signs-of-parkinsons-disease-205221" target="_blank" rel="noopener">The Conversation</a>. </em></p>

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"The beat goes on": Neil Diamond opens up about life with Parkinson’s

<p>Neil Diamond has opened up about his experience living with Parkinson’s, and how it has taken a long and uphill battle to come to terms with his 2018 diagnosis. </p> <p>In a candid interview with Anthony Mason for <em>CBS Sunday Morning</em>, the 82-year-old singer - best known for his hit song ‘Sweet Caroline’ - detailed how he moved from denial to acceptance, and the impact it has had on his life and his career ever since.</p> <p>“When the doctor told me what it was, I was just not ready to accept it,” he said. “I said, ‘oh, okay, I’ll see you whenever you want to see me, but I have work to do, so I’ll see you later’.”</p> <p>For “the first year or two”, Diamond admits he refused to accept his condition,  but as acceptance finally came to him, so did a sort of calm and peace of mind</p> <p>“I think this has just been in the last few weeks,” he explained to Mason, “but somehow, a calm has moved in and the hurricane of my life, and things have gotten very quiet.</p> <p>“And I like it. I find that I like myself better. I’m easier on people. I’m easier on myself and the beat goes on and it will go on long after I’m gone.”</p> <p>He went on to note his understanding that “this is the hand that God’s given”, and how his only option was “to make the best of it”.</p> <p>“There’s no cure, there’s no getting away from it. You can’t just say ‘okay, enough already, let’s get back to life’. It doesn’t work like that,” he said. </p> <p>“But I’ve come to accept what limitations I have and still have great days.”</p> <p>And while Diamond retired from touring in 2018 in the wake of his diagnosis, he can still find those great days in music, with his life playing out in the musical A Beautiful Noise: The Neil Diamond Musical on Broadway.</p> <p>As for how it feels to see his story performed on the stage, he admits that initially it was difficult, and that he felt some embarrassment, before going on to add that he “was flattered, and I was scared. </p> <p>“Being found out is the scariest thing you can hope for because we all have a facade. And the truth be known to all of them. I’m not some big star - I’m just me.”</p> <p>“The show is part of my psychotherapy,” he explained, “and it hurt.”</p> <p>On opening night, Diamond even returned to the stage for a singalong performance of ‘Sweet Caroline’, and as he told Mason, “I can still sing. I’ve been doing it for 50 years and I enjoy it. It’s like all the systems of my mind and my body are working as one.</p> <p>“I’ve had a pretty amazing life, it’s true.”</p> <p><em>Images: Getty</em></p>

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“I’ve written some real stinkers”: Billy Joel reveals controversial songs

<p>Singer and songwriter Billy Joel has revealed two non “woke” songs that may not have been written given today’s political climate.</p> <p>The Piano Man singer is one of the best-selling musicians to date, but the 73-year-old admitted in an interview with the <em>LA Times</em> that if he were to do it all over again, he would take away “at least 25 per cent” of his songs.</p> <p>“I’ve written some real stinkers I wish I could take back,” he said, citing ‘When in Rome’ from his 1989 album <em>Storm Front</em> and ‘C’était Toi’ from 1980’s <em>Glass Houses</em>.</p> <p>“I don’t even speak French, so I don’t know what I was doing. Sometimes I’d get six or seven songs I thought were pretty damn good, then there’d be a couple of squeeze-outs at the end just to fill up the album. I realise now I shouldn’t have done that.”</p> <p>Joel released 12 successful pop and rock albums between 1971 and 1993 but then stopped writing new material, save for <em>Fantasies and Delusions</em>, his 2001 album of classical compositions.</p> <p>Joel also told the <em>LA Times</em> that he didn’t make that decision “based on whether it was right or wrong”.</p> <p>“It just felt like it was time for me to stop writing songs,” he said. “I didn’t have the same motivation anymore. You need inspiration to create good new music, and if you don’t have it, don’t bother. Get off the treadmill, for Christ’s sake.”</p> <p>He was asked whether he considered “the current cultural and political climate” when organising a setlist, Joel said that it crossed his mind with a song such as ‘Captain Jack’, which references “the junkies and the closet queens”.</p> <p>“You mean are they woke? It crosses my mind,” he admitted.</p> <p>“But ‘Captain Jack’ has gotten real boring to me. The verse is just two chords over and over again, and it’s this dreary story of some suburban kid jacking off at home. My mind starts to wander during the song, so I don’t do it even though people want to hear it.”</p> <p>He agreed that ‘Only the Good Die Young’ was also a tough sell by ‘modern woke standards’. The song, featured on 1977’s <em>The Stranger</em>, was written from the perspective of a young man determined to have sex with a Catholic girl.</p> <p>The song has not aged well by today’s standards, with lyrics such as, “come out Virginia, don’t let me wait, you Catholic girls start much too late” and “they say there’s a heaven for those who will wait, some say it’s better, but I say it ain’t”.</p> <p>“It’s occurred to me recently that I’m trying to talk some poor innocent woman into losing her virginity because of my lust,” Joel said.</p> <p>“It’s kind of a selfish song — like, who cares what happens to you? What about what I want? But on the other hand, it was of its time. This was written in the mid-‘70s, and I was trying to seduce girls. Why bulls**t about it?”</p> <p><em>Image credit: Getty</em></p>

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Michael J Fox reveals more details about his struggle with Parkinson's

<p>Michael J. Fox has delivered an emotional and heartfelt speech, during which he recalled keeping his life-changing Parkinson’s diagnosis a secret, in fear it would impact his career.</p> <p>The famed actor was diagnosed with the disorder in 1991, at only 29 years old. It wasn’t until seven years after that he made public his health battle.</p> <p>As he accepted the Jean Hershel Humanitarian Award (an honorary Oscar recognising his philanthropic efforts), Fox said the “uncertainty” of his condition caused him to stay silent the entire time.</p> <p>"I was told I only had 10 years left to work. That was s---ty. That's what happened," he told the crowd, as per People magazine. "The hardest part of my diagnosis was grappling with the certainty of the diagnosis and the uncertainty of the situation. I only knew it would get worse. The diagnosis was definite, the progress was indefinite and uncertain."</p> <p>"Then I entered into seven years of denial, trying to make sense of it all," he recalled. "The kid who left Canada convinced that he would make anything happen, at least by working hard and by believing, now had a tall order in front of him.” He said he told "very few people" about his diagnosis and they all kept his "secret".</p> <p>"Then there were all kinds of doctors who helped me understand the physical processes that were at work, or not at work, in my brain, as the case may be," he shared. "Finally, I felt like I needed to tell everybody. I understood it would have a huge impact on my career."</p> <p>Fox eventually spoke about his diagnosis with American journalist Barbara Walters and the aftermath of the intimate interview surprised him.</p> <p>"What happened next was remarkable," he remembered. "The outpouring of support from the public at large, the beautiful reaction from all of my peers in the entertainment business, all of you, thank you, and the people that I worked with, was transformative."</p> <p><em>Images: Getty </em></p>

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COVID-19 has similar effect on brain as Parkinson’s disease

<p dir="ltr">A new study from the University of Queensland has found that being infected with COVID-19 can trigger a similar reaction in the brain to Parkinson’s disease - and they have identified a possible treatment to stop Covid’s impact on the brain in its tracks.</p> <p dir="ltr">A growing number of reports have found that Covid affects more than just our lungs, with several studies finding up to 85 percent of people with Covid, including severe, mild and asymptomatic infections, have neurological complications from being infected with the virus.</p> <p dir="ltr">This can show up in a variety of symptoms, such as headaches, dizziness, confusion, seizures, and change in mood, including depression and anxiety.</p> <p dir="ltr">The team of scientists has discovered that the virus can cause inflammation in the brain, which could make people more vulnerable to developing Parkinson's and other similar conditions.</p> <p dir="ltr">“We studied the effect of the virus on the brain’s immune cells, ‘microglia’ which are the key cells involved in the progression of brain diseases like Parkinson’s and Alzheimer’s,” Professor Woodruff said.</p> <p dir="ltr">“Our team grew human microglia in the laboratory and infected the cells with SARS-CoV-2, the virus that causes COVID-19.</p> <p dir="ltr">“We found the cells effectively became ‘angry’, activating the same pathway that Parkinson’s and Alzheimer’s proteins can activate in disease, the inflammasomes.”</p> <p dir="ltr">Inflammasomes are a kind of complex of proteins that activate inflammatory responses in the body.</p> <p dir="ltr">Dr Albornoz Balmaceda, another of the 33 authors of the study published in <em><a href="https://doi.org/10.1038/s41380-022-01831-0" target="_blank" rel="noopener">Molecular Psychiatry</a></em>, said that triggering this pathway can spark a “fire” in the brain that silently kills neurons over time in a similar way to Parkinson's and Alzheimer’s.</p> <p dir="ltr">“It’s kind of a silent killer, because you don’t see any outward symptoms for many years,” he said.</p> <p dir="ltr">“It may explain why some people who’ve had COVID-19 are more vulnerable to developing neurological symptoms similar to Parkinson’s disease.”</p> <p dir="ltr">They also found that the triggering of the inflammasome pathway was exacerbated in people who were already predisposed to developing Parkinson’s.</p> <p dir="ltr">“So if someone is already predisposed to Parkinson’s, having COVID-19 could be like pouring more fuel on that ‘fire’ in the brain,” Professor Woodruff said.</p> <p dir="ltr">“The same would apply for a predisposition for Alzheimer’s and other dementias that have been linked to inflammasomes.”</p> <p dir="ltr">While the findings are concerning, the team has also found a potential treatment that could stop the inflammation and put out the “fire” in the brain.</p> <p dir="ltr">Using inhibitory drugs developed at the University of Queensland currently being trialled with Parkinson’s patients, they found that inflammasome activation was reduced in comparison to no treatment at all.</p> <p dir="ltr">“We found it successfully blocked the inflammatory pathway activated by COVID-19, essentially putting out the fire,” Dr Balmaceda said.</p> <p dir="ltr">“The drug reduced inflammation in both COVID-19-infected mice and the microglia cells from humans, suggesting a possible treatment approach to prevent neurodegeneration in the future.”</p> <p dir="ltr">As a result, Professor Woodruff said that it means that potential treatments for Covid’s impact on the brain already exist.</p> <p dir="ltr">“Further research is needed, but this is potentially a new approach to treating a virus that could otherwise have untold long-term health ramifications,” he said.</p> <p dir="ltr"><em>Image: Getty Images</em></p>

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