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New study suggests shingles vaccine may lower dementia risk

<p>A groundbreaking new study suggests that getting vaccinated against shingles could offer protection against dementia, adding to the growing evidence linking viral infections to cognitive decline.</p> <p>Shingles is a painful and debilitating condition that occurs in individuals who have previously had chickenpox. The varicella-zoster virus, responsible for both diseases, can lie dormant for years before reactivating as shingles.</p> <p>The latest research, published recently in <em>Nature</em>, analysed data from over 280,000 older adults in Wales. The findings reveal that individuals who received the original live-virus shingles vaccine were 20% less likely to develop dementia than those who were not vaccinated.</p> <p>The study was made possible by a unique public health policy in Wales, which provided an unusual opportunity to compare similar populations. On September 1, 2013, the vaccine was offered to individuals who were 79 years old on that date but not to those who had turned 80. This created two nearly identical groups, differing only in their eligibility for the vaccine, allowing researchers from Germany and Stanford University to examine its impact on dementia risk.</p> <p>“This study is essentially like a randomised controlled trial, which is the gold standard in research,” said Dr Pascal Geldsetzer, a Stanford University assistant professor of medicine and senior author of the study.</p> <p>Previous research has suggested an association between the newer Shingrix vaccine – which replaced the live-virus version in 2020 – and a lower risk of dementia, particularly in women. However, earlier studies were unable to fully account for differences between vaccinated and unvaccinated individuals, such as overall health status.</p> <p>Dr Allison Aiello, a professor of epidemiology at Columbia University’s Aging Centre, praised the design of the Welsh study. “It’s like having a control group compared to a treated group,” Aiello, who was not involved in the research, said. “The 20% reduction in dementia risk is a pretty strong effect, which aligns with other findings that suggest herpes viruses might influence dementia.”</p> <p>Scientists do not yet fully understand how the varicella-zoster virus increases dementia risk. One theory is that viral reactivation may contribute to the buildup of abnormal proteins associated with Alzheimer’s disease. Another possibility is that shingles reactivation might also trigger herpes simplex virus (HSV), which has previously been linked to dementia.</p> <p>Herpes viruses, including HSV-1 and HSV-2, can linger in the body indefinitely, often reactivating when the immune system weakens with age. These viruses can infiltrate the central nervous system, potentially leading to brain inflammation and neurodegenerative effects. A 2024 study found that among 70-year-olds without dementia at the outset, those diagnosed with herpes simplex were more than twice as likely to develop dementia over 15 years.</p> <p>While the new study offers compelling evidence, it is not a definitive randomised controlled trial, cautioned Dr William Schaffner, an infectious disease expert at Vanderbilt University Medical Centre. “It’s provocative, interesting and exciting,” he said. However, he noted that it would be unethical to randomly assign people to receive or forgo the vaccine.</p> <p>The US FDA may eventually review the accumulating research and consider updating the shingles vaccine label to reflect a possible dementia-protection benefit, Schaffner added. Even if such an update does not occur, doctors may use these findings to encourage more people over 50 to get vaccinated.</p> <p>“There are still many eligible people who haven’t received the vaccine,” Schaffner said. “If they hear that it might help prevent dementia, that could be the push they need.”</p> <p><em>Image: Supplied</em></p>

Caring

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Acquapole lands in Sydney - Because fitness should never be dry! 

<p>Sydney Gymnastic and Aquatic Centre (SGAC) at West HQ is redefining workouts with the launch of Acquapole, an exciting aquatic fitness experience making its splashy debut in Sydney this February.  </p> <p>Forget the monotony of the gym or swimming laps – Acquapole combines the resistance of water with the strength-building benefits of pole fitness for a workout that’s effective, accessible and a whole lot of fun. </p> <p>Brad Vella, Aquatics Manager at SGAC, said Acquapole, which was designed in Italy, has proven to be a big hit in Europe given its ability to build strength, improve flexibility, and enhance coordination while being gentle on joints. </p> <p>“It’s a workout like no other, combining the strength-building benefits of pole fitness with the natural resistance of water for a full-body experience that’s as enjoyable as it is effective,” Brad Vella said. </p> <p>“It’s perfect for anyone looking to try something new, from seasoned fitness lovers to those just starting their wellness journey. </p> <p>“Acquapole brings a fresh and exciting approach to fitness for both enthusiasts and beginners. This is exactly what SGAC is all about—making fitness accessible and enjoyable for everyone.” </p> <p>The introduction of Acquapole is part of West HQ’s larger mission to bring cutting-edge fitness experiences to Greater Sydney. Acquapole is one of four innovative aquatic fitness programs now available at SGAC, alongside Acquapole Boxing, Acquapole Elastics, and SAF AQUA Drums Vibes, each offering a unique and engaging way to work out in the water. </p> <p>West HQ CEO, Richard Errington, said SGAC was committed to redefining fitness to ensure its programs continue to be to be relevant, enjoyable and dynamic.   </p> <p>“That’s why both SGAC and our One55 fitness centre continually evolve programs to make working out more rewarding by bringing fresh experiences to our members and the local community in Western Sydney,” Mr Errington said.   </p> <p>“SGAC’s Acquapole is a perfect example of how we evolve fitness  as it combines fun and innovation in a new work out experience.” </p> <p>By combining world-class fitness options with exceptional dining and entertainment, West HQ is continuously enhancing what it means to be an all-encompassing lifestyle destination in Western Sydney. </p> <p> Why Everyone’s Talking About Acquapole: </p> <ul> <li>It’s Fun: Say goodbye to dull workouts and hello to a 45 minute splash of excitement. </li> <li>It’s Low-Impact: Perfect for those looking to stay active without stressing their joints. </li> <li>It’s Inclusive: Whether you’re a fitness pro, a beginner, or somewhere in between, Acquapole welcomes you.</li> </ul> <p><em>Image credits: Supplied </em></p>

Body

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"Absolutely cooked": Old Sydney home sold for over $4.1 million

<p>A one-storey red brick home in Lane Cove, Sydney has sold for a whopping $4,165,000 at an auction on Saturday. </p> <p>The home, which boasts two bathrooms, a backyard, four bedrooms and a “traditional kitchen” has sold for more than $600,000 over reserve, despite being built between the 1920s-1950s and needing renovation. </p> <p>The home was snapped up by a British family after a fierce bidding war with six other registered buyers. </p> <p>“The people who purchased it were the opening bid. (The bidders) were actively bidding into the high threes, and two of them pushed it above the four mark,” said Sam Lloyd from McGrath Estate Agents.</p> <p>“As far as we know, they will definitely do some work to it to make it their family home.”</p> <p>Lloyd added that there was was “plenty of interest” in the 695 sqm property, with its prime location near the suburb's retail and restaurant precinct. </p> <p>The selling agent said that both himself and the owner were “surprised” by the high price of the property – which had a reserve of $3.5 million.</p> <p>“It was definitely above our expectations” he said.</p> <p>According to Domain, the median house price for a four bedroom home in Lane Cove is $3.505 million. </p> <p>Many expressed their outrage over the "crazy" price online, with freelancer chief executive Matt Barrie saying: “Sydney house prices rapidly approaching $5m. Absolutely cooked."</p> <p>“$4 million for the house, plus another $2-3 million to demolish and rebuild. The reality of living in Australia where even the top one per cent income earners face significant costs for home ownership,” another added. </p> <p>“Our economy is out of control, what a ridiculous price for an average house,” a third wrote.</p> <p>“That’s some crazy pricing! I hear Adelaide is lovely this time of year …” a fourth commented. </p> <p><em>Image: Domain</em></p>

Money & Banking

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"This ruined my life": Mum still seeking justice after horror e-bike crash

<p>Sarah was crossing on George Street in Sydney's CBD on February 2023 when she was brutally struck by a Lime e-bike rider. At the time of the accident, she was three months pregnant. </p> <p>Speaking to <em>Yahoo News</em>, Sarah explained she had been crossing the street when she heard someone yell "look out!" but before she could react, she was knocked down by the speeding vehicle. </p> <p>She claims that the bike user was illegally riding with a companion on the handle bars at the time, and fled the scene when she cried out "my baby!" </p> <p>Fortunately, Sarah's unborn daughter was unharmed during the incident, but she was left with lifelong injuries. </p> <p>"My foot was crushed, I had dislocations and many broken bones, and I needed 21 screws, two plates and two pins," Sarah said. </p> <p> "As a result of the injury, the skin on my foot began to die with fracture blisters, so I needed skin grafts as well.</p> <p>"I required six surgeries on my foot in total. One on my elbow, which was broken. One big plate and seven screws. Six weeks of non-weight bearing on my arm, and much longer on my foot. Around 12 weeks plus altogether."</p> <p>It took the mum six months after the accident to be able to walk again - three weeks before she gave birth. </p> <p>"The pain was unbelievable," she recalled. </p> <p>"The trauma was unbelievable. It was all just horrible, horrendous. It really was." </p> <p>Her family tried to seek compensation from Lime, but they deflected any blame saying that they would only take responsibility if the accident was caused by a faulty Lime bike, but not reckless riding. </p> <p>Since Lime e-bikes are rented by individuals, liability typically falls on the rider, not the company, they argued.</p> <p>The family's solicitor had also obtained CCTV footage of the incident, and had tried to get police to follow up but have been hit with multiple roadblocks since. </p> <p>"The police had their name, addresses, mobile and photos. [But] they only called one time, and went to the house one time. That's it. A high commissioner rang me to apologise, but then they still did nothing."</p> <p>Now, Sarah and her family are calling for the total ban of e-bikes in Australia. </p> <p>"They should be banned," Sarah said. "The government and Lime have just let loose motorised vehicles that can hurt riders and pedestrians, and have not covered anyone but themselves.</p> <p>"There is no policing how fast they are going. This ruined my body, my life and my first pregnancy. And nobody has been held accountable."</p> <p>While Sarah's baby was unharmed in the accident, nine months after her birth, the baby girl "was found to have tetralogy of Fallot" — a rare but serious heart defect that affects how blood flows through the heart.</p> <p>"She needed open heart surgery and will need it every 10 years. My injuries made everything a lot harder. But hopefully I can change things," Sarah said.</p> <p>"I'm certainly scarred for life."</p> <p><em>Image: Yahoo News</em></p>

Legal

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Bus crashes into suburban Sydney home

<p>A bus carrying multiple passengers has crashed into a home in south-west Sydney. </p> <p>Emergency services were called to Aplin Road in Bonnyrigg heights on Tuesday morning following reports a bus had smashed into a house. </p> <p>Fortunately nobody was in the house at the time of the crash, according to NSW police. </p> <p>Six people were treated for minor injuries, with the bus driver, a man in his 50s, taken to Liverpool Hospital with minor injuries. </p> <p>The crash caused significant damage to the home, with a part of the roof caving in, however, NSW Fire and Rescue has confirmed that the structure of the home is safe. </p> <p>An investigation into the crash is still ongoing, with a tow truck extracting the bus from the house since the accident. </p> <p><em>Image: Nine News</em></p>

Travel Trouble

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Man who worked on Harbour Bridge climbs iconic landmark

<p>An elderly man who worked on the Sydney Harbour Bridge 60 years ago has returned to Australia to climb the iconic landmark. </p> <p>Irishman Patrick Lonergan, 82, was part of a team of men who painted the Harbour Bridge in the 1960s as part of its yearly maintenance. </p> <p>Lonergan then returned to his native Ireland after his work in Sydney and has dreamed of returning ever since. </p> <p>Now in his 80s, the Sydney Bridge Climb official Instagram page has shared that Patrick has ticked off his bucket list dream of climbing the Harbour Bridge. </p> <p>"We’re honoured to have played a small role in helping him relive those special memories and capture a new photo on the Bridge," the account wrote. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/p/DE4XDIMvCgm/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/DE4XDIMvCgm/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by BridgeClimb Sydney (@bridgeclimb)</a></p> </div> </blockquote> <p>The Instagram page then shared a photo of Patrick from when he was in his 20s standing atop the bridge when he was enlisted to paint, and also a photo snapped after he completed his climb. </p> <p>The post racked up thousands of likes, with dozens of comments praising Patrick's efforts for completing the climb. </p> <p>One person wrote, "Blimey!!! No OH&S precautions back in those days! Welcome back to Oz, Paddy," while another added, "What a fantastic story. Well done Patrick!"</p> <p><em>Image credits: Instagram - Bridge Climb</em></p>

International Travel

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Ray Martin cashes in after selling luxury Sydney home

<p>Ray Martin has made a whopping $7.1 million after selling the family home he has owned on Sydney's north shore for thirty-five years.</p> <p>The veteran journalist sold the five-bedroom, three-bathroom mansion in the suburb of Waverton for a reported $8 million, after Martin and his wife Dianne bought the luxurious 1930s-era house in 1990 for $900,000.</p> <p>The beautiful home, known as Finisterre, sold for between $8 million and $8.5 million after being listed on January 1st, according to reports from <em><a href="https://www.realestate.com.au/news/ray-martins-8m-home-sale-bonanza/" target="_blank" rel="nofollow noreferrer noopener">The Daily Telegraph</a></em>.</p> <p>Located just 5km from the Sydney CBD, the gorgeous two-storey home features classic period stylings and luxurious interiors.</p> <p>The stunning home boasts impressive features such as grand scale living areas, a beautiful patio for entertaining and a glass-framed mosaic-tiled pool, while a chef's kitchen features the latest appliances and a breakfast island.</p> <p>Other highlights include a 'formal' living room, a separate family room, a home office and an open-plan dining area that opens out to the backyard and patio.</p> <p>The upper level offers a large open terrace which features views of Sydney Harbour and the city skyline.</p> <p>Other luxury features on the estate also include a wine cellar, a second-floor study and landscaped gardens.</p> <p><em>Image credits: SBS / McGrath Real Estate</em> </p>

Money & Banking

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Sydney stages major comeback in World's Best Cities ranking

<p>Sydney has staged a major comeback in the annual ranking of the World's Best Cities, rising 25 places since last year's list. </p> <p>Each year, research firm Resonance compile their list of the best cities in the world, with London coming out in the top spot for 2024 for the 10th time. </p> <p>New York replaced Paris in second place on a top-10 list dominated by European cities, but the most impressive change to the rankings came from Sydney.</p> <p>Sydney leapfrogged Melbourne in the rankings, and jumped from 35th to 10th place in just one year.</p> <p>Melbourne, which was the top-ranked Australian city last year in 31st place, also improved its position to 25th, while Perth at 83rd and Brisbane in 90th rounded out the Aussie cities. </p> <p>The World’s Best Cities rankings combines core statistics from over 400 global cities based on both resident and visitor perception indicators, rankings from trusted sources, and user-generated ratings and reviews.</p> <p>Check out the top 10 list of the World's Best Cities below. </p> <p>10. Sydney, Australia </p> <p>9. Berlin, Germany </p> <p>8. Barcelona, Spain</p> <p>7. Madrid, Spain</p> <p>6. Rome, Italy</p> <p>5. Singapore</p> <p>4. Tokyo, Japan</p> <p>3. Paris, France</p> <p>2. New York, USA</p> <p>1. London, England</p> <p><em>Image credits: Shutterstock</em></p>

International Travel

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Beloved Hollywood couple's move to Sydney

<p>Freddie Prinze Jr and Sarah Michelle Gellar have made a very low-key entry into Australia, after they were spotted at Chin Chin, a restaurant in Sydney's CBD on Saturday night with their two children. </p> <p>The beloved 90s stars have reportedly temporarily relocated to the harbour city as they film the next instalment of the <em>I Know What You Did Last Summe</em>r horror franchise, 27 years after the release of the first movie, according to <em>The Daily Telegraph</em>. </p> <p>The new film, titled I Never Forget What You Did Last Summer, will see Prinze Jr, 48, reprise his role as Ray Bronson.</p> <p>The horror film is expected to be released next year through Sony Pictures. </p> <p>Prinze Jr and Gellar's first date was not intentional, as they had plans for dinner with a mutual friend who then cancelled. </p> <p>“We decided to have dinner anyway and never looked back,” Gellar told <em>People</em> in 2002.</p> <p>They tied the knot in Mexico that same year. </p> <p>“One day, I just knew we were gonna get married and I knew I was gonna propose. I didn’t know when or how,” Prinze Jr told <em>People</em> in 2020.</p> <p>“And so I did and fortunately, she was on the same page. My instincts were correct.”</p> <p>In 2009 they welcomed their daughter Charlotte and in 2012 they had their son Rocky. </p> <p><em>Image: Instagram</em></p>

Relationships

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Alan Jones once seemed unassailable. What ended it was a peculiarly Sydney story of media, politics and power

<div class="theconversation-article-body"><em><a href="https://theconversation.com/profiles/denis-muller-1865">Denis Muller</a>, <a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em></p> <p>For decades it seemed Alan Jones was unassailable.</p> <p>A finding against him of professional misconduct by the Australian Broadcasting Authority (2000); a <a href="https://www.smh.com.au/entertainment/tv-and-radio/tribunal-upholds-that-jones-incited-hatred-20121002-26x8h.html">finding</a> that he incited hatred, serious contempt and severe ridicule of Lebanese Muslims (2009); propositions of violence against two women prime ministers (<a href="https://www.abc.net.au/news/2011-10-20/alan-jones-says-gillard-remark-best-left-unsaid/3579658">2011</a> and <a href="https://www.abc.net.au/news/2020-05-21/alan-jones-breached-rules-in-jacinda-ardern-comment/12271476">2019</a>); verdicts against him and his employer amounting to millions of dollars in defamation actions (most notably <a href="https://www.abc.net.au/news/2018-09-12/alan-jones-defamed-wagners-court-decision-brisbane-qld/10230384">one for $3.75 million</a> in 2018): none of these ended his career.</p> <p>Quite the reverse. Only weeks after the Australian Broadcasting Authority found in its “cash for comments” inquiry that Jones and others had misled their listeners by presenting paid endorsements as editorial opinion, he was hosting an event for then prime minister John Howard.</p> <p>Howard was to become a fixture on the Jones program throughout the 11 years of his prime ministership.</p> <p>The day after the Australian Communications and Media Authority found Jones was likely to have encouraged violence and vilification of Australians of Lebanese and Middle Eastern background, Howard <a href="https://www.theage.com.au/national/jones-wins-friends-in-high-places-20070412-ge4n4f.html">described him</a> as “an outstanding broadcaster”. “I don’t think he’s a person who encourages prejudice in the Australian community, not for one moment, but he is a person who articulates what a lot of people think.”</p> <p>By 2001, Jones had become a kind of on-air policy-maker for the New South Wales government. In November that year, he dined with the then Labor premier, Bob Carr. They discussed a range of government policies, particularly policing. At that time, Jones was a relentless critic of the NSW police.</p> <p>The following week, <a href="https://www.abc.net.au/news/2012-10-01/newton-alan-jones/4288824">Carr dispatched</a> his police minister-designate, Michael Costa, to Jones’s home to discuss policing policy.</p> <p>In 2011 he said Julia Gillard, then Australia’s prime minister, should be taken out to sea and dumped in a chaff bag. In August 2019 he said Scott Morrison, who was then Australia’s prime minister, should “shove a sock” down the throat of his New Zealand counterpart Jacinda Ardern.</p> <p>He was an outspoken climate-change denier, and these grotesqueries were part of his campaign against political recognition of this reality.</p> <figure><iframe src="https://www.youtube.com/embed/Od6I1YbrBoM?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>Jones’s power, which made him so apparently untouchable, came from his weaponising of the microphone for conservative political ends in ways that resonated with his vast and rusted-on audience of largely working-class older people across Sydney’s sprawling western suburbs.</p> <p>These suburbs contain many marginal state and federal electorates where the fates of governments can be decided. Their populations provide fertile ground for seeding by right-wing radio shock jocks, of whom Jones and his rival John Laws were pre-eminent examples.</p> <p>In Australia, this is a peculiarly Sydney phenomenon. It is not seen to the same degree in any other capital city, even though they too have large areas of socioeconomic disadvantage like western Sydney.</p> <p>Why that should be so is a complex question, but there are aspects of Sydney life that mark it out as different. It is really two cities. One is the largely prosperous and scenically dazzling east and north. The other, much larger, consists of dreary tracts of increasingly crowded housing stretching for many kilometres to the west and southwest.</p> <p>In Sydney argot, the inhabitants of these respective worlds are called “silvertails” and “fibros”, the latter referring to the cladding of the homes that proliferated in western Sydney between and after the two world wars.</p> <p>This two-cities effect makes the gap between the “haves” and the “have-nots” highly visible in a way that has no parallel in other Australian capitals. It engenders deep-seated grievance and cynicism, which the likes of Jones, who lives in a multimillion-dollar apartment on Circular Quay, have relentlessly exploited.</p> <p>Jones coined the term “Struggle Street” to encapsulate the hardships of his listeners’ lives.</p> <p>To these powerless people, Jones and Laws gave a voice, and as their audiences grew, prime ministers and premiers courted and feared them.</p> <p>In the end, Jones’s impregnability was breached by not the power elite turning on one of their own, but by the journalism of a redoubtably tenacious Sydney Morning Herald investigative reporter, Kate McClymont.</p> <p>In December 2023, <a href="https://www.smh.com.au/national/he-d-go-the-grope-alan-jones-accused-of-indecently-assaulting-young-men-20231205-p5epai.html">she claimed</a> Jones had used his position of power, first as a teacher and later as the country’s top-rating radio broadcaster, to allegedly prey on a number of young men.</p> <p>In response to McClymont’s work, the NSW police set up Strike Force Bonnefin, run by the State Crime Command’s Child Abuse Squad, to conduct an investigation into Jones.</p> <figure><iframe src="https://www.youtube.com/embed/0ExkpCtfmA8?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>On November 18 2024, Jones was arrested at his Circular Quay home and charged initially with 24 sexual offences against eight males. The following day, two <a href="https://www.abc.net.au/news/2024-11-19/alan-jones-charged-with-additional-offences-nsw-police/104617680">additional charges</a> were laid involving a ninth male.</p> <p>Through his lawyers, Jones has denied the charges and was bailed to appear in Sydney’s Downing Centre Local Court on December 18. He <a href="https://www.smh.com.au/national/alan-jones-arrested-over-allegations-he-indecently-assaulted-young-men-20241118-p5krdu.html">was ordered</a> to surrender his passport and not to contact or harass the alleged victims.</p> <p>The charges relate to offences alleged to have been committed by Jones between 2001 and 2019, the youngest alleged victim being 17 at the time.</p> <p>Those dates coincide almost exactly with Jones’s most influential years, from 2002 to 2020.</p> <p>McClymont <a href="https://www.smh.com.au/national/a-stunning-development-kate-mcclymont-on-alan-jones-arrest-and-what-s-next-20241118-p5krln.html">has spoken</a> about the reluctance of some of her interviewees to speak, for fear of what Jones might do: "People were too afraid to take on Alan Jones. Once a couple of people came forward, and some people were happy to be publicly named, that gave confidence for other people to come forward.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/243942/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" />"</p> <p><a href="https://theconversation.com/profiles/denis-muller-1865"><em>Denis Muller</em></a><em>, Senior Research Fellow, Centre for Advancing Journalism, <a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/alan-jones-once-seemed-unassailable-what-ended-it-was-a-peculiarly-sydney-story-of-media-politics-and-power-243942">original article</a>.</em></p> </div>

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New study suggests weight loss drugs like Ozempic could help with knee pain. Here’s why there may be a link

<div class="theconversation-article-body"> <p><em><a href="https://theconversation.com/profiles/giovanni-e-ferreira-1030477">Giovanni E. Ferreira</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/christina-abdel-shaheed-425241">Christina Abdel Shaheed</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p>The drug semaglutide, commonly known by the brand names Ozempic or Wegovy, was <a href="https://theconversation.com/the-rise-of-ozempic-how-surprise-discoveries-and-lizard-venom-led-to-a-new-class-of-weight-loss-drugs-219721">originally developed</a> to help people with type 2 diabetes manage their blood sugar levels.</p> <p>However, researchers have discovered it may help with other health issues, too. Clinical trials show semaglutide can be effective for <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2032183">weight loss</a>, and hundreds of thousands of people around the world are using it <a href="https://theconversation.com/considering-taking-a-weight-loss-drug-like-ozempic-here-are-some-potential-risks-and-benefits-219312">for this purpose</a>.</p> <p>Evidence has also shown the drug can help manage <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2306963">heart failure</a> and <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2403347">chronic kidney disease</a> in people with obesity and type 2 diabetes.</p> <p>Now, a study published in the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2403664">New England Journal of Medicine</a> has suggested semaglutide can improve knee pain in people with obesity and osteoarthritis. So what did this study find, and how could semaglutide and osteoarthritis pain be linked?</p> <h2>Osteoarthritis and obesity</h2> <p>Osteoarthritis is a common joint disease, affecting <a href="https://www.aihw.gov.au/reports/chronic-musculoskeletal-conditions/osteoarthritis">2.1 million Australians</a>. Most people with osteoarthritis <a href="https://theconversation.com/do-you-have-knee-pain-from-osteoarthritis-you-might-not-need-surgery-heres-what-to-try-instead-236779">have pain</a> and find it difficult to perform common daily activities such as walking. The knee is <a href="https://pubmed.ncbi.nlm.nih.gov/37675071/">the joint most commonly affected</a> by osteoarthritis.</p> <p>Being overweight or obese is a <a href="https://pubmed.ncbi.nlm.nih.gov/25447976/">major risk factor</a> for osteoarthritis in the knee. The link between the two conditions <a href="https://pubmed.ncbi.nlm.nih.gov/26821091/">is complex</a>. It involves a combination of increased load on the knee, <a href="https://www.nature.com/articles/s41413-023-00301-9">metabolic factors</a> such as high cholesterol and high blood sugar, and inflammation.</p> <p>For example, elevated blood sugar levels increase the production of inflammatory molecules in the body, which can damage the cartilage in the knee, and lead to the <a href="https://pubmed.ncbi.nlm.nih.gov/30712918/">development of osteoarthritis</a>.</p> <p>Weight loss is strongly recommended to reduce the pain of knee osteoarthritis in people who are overweight or obese. <a href="https://pubmed.ncbi.nlm.nih.gov/31908149/">International</a> and <a href="https://www.safetyandquality.gov.au/sites/default/files/2024-08/osteoarthritis-knee-clinical-care-standard-2024.pdf">Australian guidelines</a> suggest losing as little as 5% of body weight can help.</p> <p>But losing weight with just diet and exercise can be difficult for many people. <a href="https://pubmed.ncbi.nlm.nih.gov/26180980/">One study</a> from the United Kingdom found the annual probability of people with obesity losing 5% or more of their body weight was less than one in ten.</p> <p>Semaglutide has recently entered the market as a potential alternative route to weight loss. It comes from a class of drugs known as GLP-1 receptor agonists and works by increasing a person’s sense of fullness.</p> <h2>Semaglutide for osteoarthritis?</h2> <p>The rationale for the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2403664">recent study</a> was that while we know weight loss alleviates symptoms of knee osteoarthritis, the effect of GLP-1 receptor agonists was yet to be explored. So the researchers set out to understand what effect semaglutide might have on knee osteoarthritis pain, alongside body weight.</p> <p>They randomly allocated 407 people with obesity and moderate osteoarthritis into one of two groups. One group received semaglutide once a week, while the other group received a placebo. Both groups were treated for 68 weeks and received counselling on diet and physical activity. At the end of the treatment phase, researchers measured changes in knee pain, function, and body weight.</p> <p>As expected, those taking semaglutide lost more weight than those in the placebo group. People on semaglutide lost around 13% of their body weight on average, while those taking the placebo lost around 3% on average. More than 70% of people in the semaglutide group lost at least 10% of their body weight compared to just over 9% of people in the placebo group.</p> <p>The study found semaglutide reduced knee pain significantly more than the placebo. Participants who took semaglutide reported an additional 14-point reduction in pain on a 0–100 scale compared to the placebo group.</p> <p>This is much greater than the pain reduction in another <a href="https://pubmed.ncbi.nlm.nih.gov/36511925/">recent study</a> among people with obesity and knee osteoarthritis. This study investigated the effects of a diet and exercise program compared to an attention control (where participants are provided with information about nutrition and physical activity). The results here saw only a 3-point difference between the intervention group and the control group on the same scale.</p> <p>The amount of pain relief reported in the semaglutide trial is also larger than that reported with commonly used pain medicines such as <a href="https://pubmed.ncbi.nlm.nih.gov/35442752/">anti-inflammatories</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/35137418/">opioids</a> and <a href="https://www.bmj.com/content/372/bmj.m4825">antidepressants</a>.</p> <p>Semaglutide also improved knee function compared to the placebo. For example, people who took semaglutide could walk about 42 meters further than those on the placebo in a six-minute walking test.</p> <h2>How could semaglutide reduce knee pain?</h2> <p>It’s not fully clear how semaglutide helps with knee pain from osteoarthritis. One explanation may be that when a person loses weight, there’s less stress on the joints, which reduces pain.</p> <p>But recent studies have also suggested semaglutide and other GLP-1 receptor agonists might have <a href="https://www.sciencedirect.com/science/article/pii/S1043661822002651">anti-inflammatory</a> properties, and could even protect against <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6731440/">cartilage wear and tear</a>.</p> <p>While the results of this new study are promising, it’s too soon to regard semaglutide as a “miracle drug” for knee osteoarthritis. And as this study was funded by the drug company that makes semaglutide, it will be important to have independent studies in the future, to confirm the findings, or not.</p> <p>The study also had strict criteria, excluding some groups, such as those taking opioids for knee pain. One in seven Australians seeing a GP for their knee osteoarthritis <a href="https://pubmed.ncbi.nlm.nih.gov/34527976/">are prescribed opioids</a>. Most participants in the trial were white (61%) and women (82%). This means the study may not fully represent the average person with knee osteoarthritis and obesity.</p> <p>It’s also important to consider semaglutide can have a range of <a href="https://theconversation.com/considering-taking-a-weight-loss-drug-like-ozempic-here-are-some-potential-risks-and-benefits-219312">side effects</a>, including gastrointestinal symptoms and fatigue.</p> <p>There are some concerns that semaglutide could reduce <a href="https://www.sciencealert.com/experts-are-concerned-drugs-like-ozempic-may-cause-muscle-loss">muscle mass</a> and <a href="https://www.healthline.com/health-news/ozempic-muscle-mass-loss">bone density</a>, though we’re still learning more about this.</p> <p>Further, it can be difficult to access.</p> <h2>I have knee osteoarthritis, what should I do?</h2> <p>Osteoarthritis is a disease caused by multiple factors, and it’s important to take <a href="https://www.safetyandquality.gov.au/standards/clinical-care-standards/osteoarthritis-knee-clinical-care-standard/information-consumers-osteoarthritis-knee-clinical-care-standard">a multifaceted approach</a> to managing it. Weight loss is an important component for those who are overweight or obese, but so are other aspects of <a href="https://theconversation.com/do-you-have-knee-pain-from-osteoarthritis-you-might-not-need-surgery-heres-what-to-try-instead-236779">self-management</a>. This might include physical activity, pacing strategies, and other positive lifestyle changes such as improving sleep, healthy eating, and so on.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/243159/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/giovanni-e-ferreira-1030477">Giovanni E. Ferreira</a>, NHMRC Emerging Leader Research Fellow, Institute of Musculoskeletal Health, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/christina-abdel-shaheed-425241">Christina Abdel Shaheed</a>, Associate Professor, School of Public Health, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p><em>Image credits: Shutterstocl</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/new-study-suggests-weight-loss-drugs-like-ozempic-could-help-with-knee-pain-heres-why-there-may-be-a-link-243159">original article</a>.</em></p> </div>

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How hip pain led Sydney karate master to life-changing weight loss journey

<div> <p>Sydney-based karate instructor and personal trainer Glenn Stephenson knows the toll that joint pain and extra weight can take on physical activity. Despite decades of experience as a martial arts coach, Glenn found himself increasingly limited by severe hip pain and unwanted weight gain.</p> </div> <div> <p>In 2021, at 95 kilograms, the 64-year-old’s arthritis and reduced mobility affected not only his work but also his confidence. “I couldn’t move around like I wanted to, and as a master instructor, it felt wrong to be teaching students while carrying so much extra weight,” he admits.</p> </div> <div> <p>Glenn’s pain and discomfort prompted him to make a drastic change. Instead of resorting to extreme dieting, he adopted a more sustainable approach to weight loss to reduce joint and liver inflammation, and regain his mobility. He shed 20 kilograms and now walks four kilometres daily. “I can move better, my mental health has improved, and I feel more capable of guiding my students,” he says.</p> </div> <div> <p>Today, Glenn encourages others struggling with weight to take a balanced approach to fitness and health. “I look the part now, which gives me confidence as a master instructor to show my students that staying active is achievable at any age.”</p> </div> <div> <p>Dietitian Kirby Sorenson, from health platform <a title="https://www.getmosh.com.au/?utm_term=mosh&amp;utm_campaign=Cross_Search_Brand_Mosh&amp;utm_source=paid-search&amp;utm_medium=adwords&amp;utm_content=100740202037&amp;hsa_acc=5792635568&amp;hsa_cam=1701000406&amp;hsa_grp=100740202037&amp;hsa_ad=697110582898&amp;hsa_src=g&amp;hsa_tgt=kwd-295213997936&amp;hsa_kw=mosh&amp;hsa_mt=p&amp;hsa_net=adwords&amp;hsa_ver=3&amp;gclid=CjwKCAiAxKy5BhBbEiwAYiW--5qfGzQVQBG-CmA6baVMEeP5Zmk_oB_GOstA1n2vabFrLzbeDrEEnxoCM4YQAvD_BwE" href="https://www.getmosh.com.au/?utm_term=mosh&amp;utm_campaign=Cross_Search_Brand_Mosh&amp;utm_source=paid-search&amp;utm_medium=adwords&amp;utm_content=100740202037&amp;hsa_acc=5792635568&amp;hsa_cam=1701000406&amp;hsa_grp=100740202037&amp;hsa_ad=697110582898&amp;hsa_src=g&amp;hsa_tgt=kwd-295213997936&amp;hsa_kw=mosh&amp;hsa_mt=p&amp;hsa_net=adwords&amp;hsa_ver=3&amp;gclid=CjwKCAiAxKy5BhBbEiwAYiW--5qfGzQVQBG-CmA6baVMEeP5Zmk_oB_GOstA1n2vabFrLzbeDrEEnxoCM4YQAvD_BwE" data-outlook-id="bc4b923a-a4a3-4af0-80db-e837cd64b4c7">Mosh</a>, is encouraging Australians to ditch the Body Mass Index (BMI) in favour of more modern diagnostics to determine the risk of disease linked to higher body fat, declaring it’s unfairly categorising people as being overweight.</p> </div> <div> <p>Ms Sorenson says knowing your Body Roundness Index (BRI) as well as your Basal Metabolic Rate (BMR) can more accurately predict the risk of diseases like high blood pressure, type 2 diabetes and heart disease because it works out body fat levels based on height and waist circumference, rather than the BMI method which relies on height and weight.</p> </div> <div> <p>“BMI has long been criticised for inaccurately categorising people as overweight or obese because it doesn’t differentiate between those who carry a lot of muscle and individuals with fat in the wrong places,” Ms Sorenson says.</p> </div> <div> <p>“The problem is that it only looks at overall weight, while the BRI focuses on fat held around the abdomen which is the riskiest fat in terms of overall health.</p> </div> <div> <p>Once the BRI is determined, Ms Sorenson says it can help to know your Basal Metabolic Rate, which is largely determined by your total lean mass to help determine a healthy path to maintaining a healthy weight range.</p> </div> <div> <p>“The basal metabolic rate or BMR gives you an idea of how many calories your body burns doing the bare minimum; breathing, blood circulation, brain and nerve function. It can vary greatly from person to person, which explains why individual weight loss journeys can be so different,” Ms Sorenson said.</p> </div> <div> <p>For more information visit Moshy’s online <a title="https://www.getmoshy.com.au/weight-loss/basal-metabolic-rate-calculator?srsltid=AfmBOoobS-PiI_4sJn2ykpEG6vzq6qkvQXammfLv4Rm-mS5nwll6EN0m" href="https://www.getmoshy.com.au/weight-loss/basal-metabolic-rate-calculator?srsltid=AfmBOoobS-PiI_4sJn2ykpEG6vzq6qkvQXammfLv4Rm-mS5nwll6EN0m" data-outlook-id="800f9af2-0a34-4ac4-801b-d16714c7ec2e">BMR calculator</a>.</p> <p><em>Image credits: Supplied</em></p> </div>

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Having the ‘right’ friends may hold the secret to building wealth, according to new study on socioeconomic ties

<div class="theconversation-article-body"><em><a href="https://theconversation.com/profiles/brad-cannon-2216202">Brad Cannon</a>, <a href="https://theconversation.com/institutions/binghamton-university-state-university-of-new-york-2252">Binghamton University, State University of New York</a></em></p> <p>Having wealthy people in your social network significantly boosts the likelihood that you’ll participate in stock markets and savings plans, according to a new working paper I co-authored.</p> <p>My colleagues and I <a href="https://www.nber.org/system/files/working_papers/w32186/w32186.pdf">recently conducted research</a> on social finance to understand the ways in which social networks affect stock market participation and savings behavior. This is important because a substantial fraction of households in the U.S., particularly <a href="https://www.axios.com/2023/10/18/percentage-americans-own-stock-market-investing">lower-income families, do not own stocks</a>.</p> <p>Given that the total return to the U.S. stock market from 1980 through September 2024 has been over 12,000% – for example, US$1,000 <a href="https://ofdollarsanddata.com/sp500-calculator/">invested in the S&amp;P 500</a> in 1980 would be worth $121,350 today – this creates a disparity in wealth for those who participate relative to those who do not. Understanding why some people invest and others don’t is important for addressing social concerns such as rising inequality.</p> <p>In our study, we looked at <a href="https://academic.oup.com/ej/advance-article/doi/10.1093/ej/ueae074/7720537">social capital</a>, which is a measure of the value that comes from being in a group or having dense social networks. Researchers have found that social capital can have positive impacts on individuals and communities, spurring innovation, <a href="https://www.nature.com/articles/s41586-022-04996-4">economic prosperity</a> and better health outcomes. We used friendship data from Facebook to measure different aspects of social networks by county in the U.S. We combined this data with tax information from the Internal Revenue Service about investments and savings.</p> <p>We found that in counties where friendships with prosperous individuals are more common, investment and savings tend to be higher. Moreover, we found that having these friendships with wealthy individuals plays a more important role in shaping financial behaviors than two other aspects of social capital we looked at in our study: having a tight group of friends and living in a community with strong civic engagement.</p> <p>Of course, making wealthy friends alone does not guarantee you’ll invest or save more. But perhaps knowing people who invest makes it less daunting and fraught, particularly if those friends can serve as a resource and sounding board.</p> <p><em>“Friends with Benefits: Social Capital and Household Financial Behavior” was co-authored by <a href="https://www.marshall.usc.edu/personnel/david-hirshleifer">David Hirshleifer</a> and <a href="https://hankamer.baylor.edu/person/joshua-thornton">Joshua Thornton</a>.</em><!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/239370/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/brad-cannon-2216202">Brad Cannon</a>, Assistant Professor of Finance, <a href="https://theconversation.com/institutions/binghamton-university-state-university-of-new-york-2252">Binghamton University, State University of New York</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/having-the-right-friends-may-hold-the-secret-to-building-wealth-according-to-new-study-on-socioeconomic-ties-239370">original article</a>.</em></p> </div>

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New research calls for later-in-life driving lessons

<p>New research has shown that older drivers should be coming forward to test and update their driving skills to keep people safer on the road, and keep senior drivers behind the wheel for longer. </p> <p>A new website launched by the University of New South Wales (UNSW) and neuroscience institute NeuRA aims to help drivers aged in their 50s and above stay safe when driving, while also helping to update their skills to keep them on the roads for longer. </p> <p>Cognitive aging expert and UNSW professor Kaarin Anstey told <em><a href="https://www.9news.com.au/national/how-old-is-too-old-to-drive-in-australia-new-research-shows-ageing-motorists-should-have-driving-lessons/6a470fa9-f0c3-4571-a229-672e689f1e76" target="_blank" rel="noopener">9News</a></em> later-in-life driving lessons were crucial as our population grows and ages.</p> <p>"We obviously want people to stay on the road as long as it's safe for them to do so. And that's the issue: they have to be safe on the road," Anstey explained.</p> <p>"That's the point of the website, to empower older drivers, family members and health professionals."</p> <p>"We've been working on this issue of older drivers for over 20 years because the second biggest cause of injury in older adults is motor vehicle accidents or crashes (after falls)."</p> <p>Anstey said her research in <a href="https://www.unsw.edu.au/newsroom/news/2024/11/should-age-determine-how-long-drive-car" target="_blank" rel="noopener">The Better Drive Study</a> analysed how the driving habits of older motorists changed if they had a refresher course. </p> <p>"A lot of people got their licence in an era where the cars were different, the roads were different, the road rules were different," she said.</p> <p>"We just feel there's a certain amount of improvement that probably all of us, not just the older age group but lots of people, could benefit in refreshing their driving skills."</p> <p>Anstey's pilot study, that followed motorists aged over 65 over 12 months, found older people were more likely to develop bad habits such as not checking blind spots or not keeping up to date with key road rules.</p> <p>She said people who did the driving lessons had a "big improvement" in their safety on the road.</p> <p>Later-in-life lessons could also identify if a person should be looking at giving up their licence, as Anstey added, "Sometimes there's people who we find who are not very safe drivers, or who have an impairment that they may not have been aware of."</p> <p>When asked what they thought of the initiative, some older drivers told <em>9News</em>, "I think it's a good idea, there are some older people who definitely need a refresher but there are some that are still quite good."</p> <p>"I'd rather not go through those grills but I guess for everyone's safety it's a very good thing," another added.</p> <p><em>Image credits: Shutterstock</em></p>

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Breakthrough study finds genetic link to Parkinson's and ADHD

<p>A major scientific study has found a surprising link between the genes that control brain size and the risk of brain-related conditions. </p> <p>A Queensland Institute of Medical Research Associate Professor Miguel Renteria led an international team of experts who scanned DNA data and MRI scans from 76,000 participants.</p> <p>“Genetic variants associated with larger brain volumes in key brain regions also increase the risk of Parkinson’s disease, while variants linked to smaller brain volumes in key regions are associated with an increased risk of ADHD,” Renteria said. </p> <p>“It brings us closer to answering key questions about how genetics influence brain structure, and how we can potentially treat these conditions in future.”</p> <p>Parkinson’s Australia CEO Olivia Nassaris has celebrated the results of the study, saying the surprising results open the door to future treatment options for Parkinson’s, which currently has no cure or cause.</p> <p>“The more answers we have the closer we are to understanding this condition,” she said.</p> <p>Michael Wiseman, who has been living with Parkinson’s for eight years, said he is pleased more research is being done about the neurodegenerative condition.</p> <p>“I know it’s not going to benefit me in any way, as far as a cure or anything … I just hope they keep going, kicking some goals and finding results because it’s an insidious sort of thing, it’s a passenger I’ll have until I go to the grave.”</p> <p><em>Image credits: Shutterstock </em></p>

Caring

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Father breaks silence after wife and two children die in tragic drowning

<p>Hoai Nguyen, 32, and her two children, Mitchell, 7, and Hazel, 5, were enjoying a day out at Shearer Park in south-west Sydney, and were walking down to a small pier on the waterfront before they were spotted <a href="https://www.oversixty.com.au/health/caring/unimaginable-sorrow-mother-and-two-children-drown-during-family-outing" target="_blank" rel="noopener">struggling in the Georges River</a> about 10.15am on Saturday. </p> <p>Hoai was pulled to shore shortly afterwards, but despite desperate attempts by rescuers and bystanders she could not be revived. </p> <p>The bodies of the two children were recovered a few hours later, metres from a jetty. </p> <p>The children's father, Dinh Nguyen, had been at work during the incident and only found out about the tragedy when police showed up at his house. </p> <p>He has since broken his silence, and told <em>The Sydney Morning Herald</em> that his wife was navigating a mental illness prior to her death. </p> <p>“She has bipolar disorder, and she has some ups and some downs,” he told the publication. </p> <p>“She takes medicine. Sometimes it works, sometimes it doesn’t.”</p> <p>He also recalled one of the last conversations the couple had, the night prior to the tragedy. </p> <p>“She told me the last night she didn’t sleep so she wanted to stay at home,” he said.</p> <p>According to <em>The Daily Telegraph</em>, detectives are now probing whether the incident was premeditated as they continue their investigations into the tragedy. </p> <p>The southwest Sydney community has since rallied around the family's loved ones, with bouquets of flowers and tributes seen at the riverbank as part of a growing memorial. </p> <p>A close friend of the family, Sarah Vu, has also organised a <a href="https://www.gofundme.com/f/hoai-mitchell-and-hazel-nguyen" target="_blank" rel="noopener">GoFundMe</a> page for the family which has since raised over $60,600 of their $40,000 goal. </p> <p>“I sincerely thank the entire community for their contributions,” she wrote in a social media tribute on Monday.</p> <p>“The family have decided to bring Hoai and the kids back to Vietnam.</p> <p>“The fund has currently exceeded my expectations, but I will keep the link open for anyone who still wants to donate.”</p> <p>"All we can do now is pray for you and the little ones to depart peacefully,” she added with a video of two young kids holding hands and skipping down a street together. </p> <p><em><strong>Need to talk to someone? Don't go it alone.</strong></em></p> <p><em>Lifeline: <strong>13 11 14</strong>, <a href="https://www.lifeline.org.au/" target="_blank" rel="noopener">lifeline.org.au </a></em></p> <p><em>SANE Support line and Forums: <strong>1800 187 263,</strong> <a href="https://saneforums.org/" target="_blank" rel="noopener">saneforums.org</a></em></p> <p><em>Headspace: <strong>1800 650 890,</strong> <a href="https://headspace.org.au/" target="_blank" rel="noopener">headspace.org.au</a></em></p> <p><em>Beyond Blue: <strong>1300 224 635</strong>, <a href="beyondblue.org.au" target="_blank" rel="noopener">beyondblue.org.au </a></em></p> <p><em>Images: Facebook/ GoFundMe</em></p>

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"Unimaginable sorrow": Mother and two children drown during family outing

<p>A mother and two children have died after struggling to swim in a Sydney waterway, with tributes and donations flowing in to support the grieving father.</p> <p>Hoai Nguyen, 32, and her two children, Mitchell, seven, and Hazel, five, were enjoying a day out at Shearer Park in south-west Sydney on Sunday, when they were spotted in distress in the waters of the Georges River. </p> <p>Hoai was pulled from the river, but despite the best efforts of bystanders and paramedics, she was unable to be revived. </p> <p>Police and volunteers from the State Emergency Service launched a large search and rescue operation for the two children, with divers locating their bodies in the water hours later, metres from a jetty.</p> <p>According to <em><a href="https://www.9news.com.au/national/sydney-news-georges-river-mother-hoai-nguyen-and-children-drown-lansvale/c8601ec9-47a1-4a79-8a12-67c3ff18f3ea" target="_blank" rel="noopener">9News</a></em>, the children's father and Hoai's husband had been at work during the incident and was only alerted to the tragedy when police showed up at his house. </p> <p>A <a href="https://www.gofundme.com/f/hoai-mitchell-and-hazel-nguyen" target="_blank" rel="noopener">GoFundMe</a> page has been set up by a family friend to support the children's father, Hoai's husband, and their one-year-old brother during the "time of unimaginable sorrow".</p> <p>"A beloved mother and her two young children tragically drowned... leaving behind a profound void in our hearts and a father and baby who is only 1 years old," the fundraiser reads.</p> <p>An investigation into how the mother and her children ended up in the water is ongoing, as NSW Police acting superintendent Luke Scott yesterday described the tragedy as "beyond words".</p> <p><em>Image credits: GoFundMe</em></p>

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Father reveals alarming details after young model found dead in Sydney brewery

<p>Savana Calvo, 27, was <a href="https://www.oversixty.com.au/health/caring/tragedy-as-young-model-dies-in-popular-brewery" target="_blank" rel="noopener">found dead</a> in the bathroom of Young Henry's brewery in Newtown, at around 11.30pm on Wednesday. </p> <p>As tributes pour in for the young model, her father, Daniel Paul Calvo has revealed that she allegedly received death threats in the week prior to her death. </p> <p>“As her father, I knew very well that she was being harassed and stalked, and I tried to intervene. Although we were very close, daughters only tell their parents so much,” he told <em>The Daily Telegraph</em>. </p> <p>“There’s more and more coming out, she was involved with some dodgy young guys, owed money, and leading up to last week she was getting multiple death threats.”</p> <p>The death threats that were allegedly sent to her will form part of an ongoing investigation into her death, NSW Police have confirmed. </p> <p>Friends and family have paid tribute to the fallen model, and started a GoFundMe page to cover her funeral costs. They said that “those who knew her best, knew that she went through some trying times." </p> <p>“She was a cherished daughter, sister and friend who brought so much love and light into all of our lives.</p> <p>She will be deeply missed by all who knew her.”</p> <p>The fundraiser has since raised over $30,000 for the model. </p> <p><em>Images: Instagram/ Google Maps</em></p>

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Tragedy as young model dies in popular brewery

<p>A young woman has died suddenly at a popular Sydney brewery. </p> <p>Savana Calvo, 27 tragically passed away at the Young Henry's brewery in Newtown at about 11.30pm last Wednesday. </p> <p>Her death is not being treated as suspicious, but her loved ones have revealed she had been going through "trying times" before her death. </p> <p>“It is with heavy hearts that we announce the passing of our beloved Savana, 27,” the model's friend Adam St John-Foti wrote online. </p> <p>“She was a cherished daughter, sister and friend who brought so much love and light into all of our lives.</p> <p>“She will be deeply missed by all who knew her.</p> <p>“Those who knew her best, knew that she was went through some trying time these past in recent times that led to her tragic passing.”</p> <p>Friends have rallied around her family, with St John-Foti setting up a <a href="https://www.gofundme.com/f/savana-calvo" target="_blank" rel="noopener">GoFundMe</a> page, which has so far raised over $28,000 to help her family cope with funeral costs. </p> <p>He added that he family were "spellbound" by the outpouring of support. </p> <p>“Your generosity will make a meaningful difference in ensuring that Savana is laid to rest with the dignity, respect, and celebration she deserves,” the page read. </p> <p>“We also appreciate your thoughts, prayers, and messages of support during this difficult time.</p> <p>“Your kindness means the world to Savana’s family as we navigate through our grief.”</p> <p>Another friend of the model has remembered her as a  “smiling and a kind gentle soul” who would  “be missed so much". </p> <p>“Fly high beautiful angel. I haven’t stopped thinking of you since I found out about your passing ... I will miss you Savvy.”</p> <p>Coopers Hotel, another Newtown institution has also paid tribute to Calvo, saying: “It is with heavy hearts that Newtown grieves the loss of a beloved member of its community Savana C." </p> <p>“Sav’s family has started a go fund me to help with funeral costs, please donate if you can.”</p> <p>Young Henrys was closed to the public on Thursday with police spotted on the outside. There is no suggestion of any wrongdoing by the brewery. </p> <p><em>Images: GoFundMe/ Instagram</em></p>

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"Green cordial" water in Sydney harbour baffles residents

<p>A bay in Sydney Harbour has turned neon green, with authorities currently investigating the cause. </p> <p>Locals were baffled when they saw the bay along Hipwood Street in Kirribilli, near Milsons Park, turn bright green at about 3pm on Wednesday, with many calling the incident "unusual". </p> <p>Firefighters said they were  "alerted to a large spill of fluorescent green material flowing into the harbour".</p> <p>One local described the water as "green cordial" and said it resembled "radioactive stuff you see in superhero movies".</p> <p>NSW Fire and Rescue then conducted several tests and said the water is not toxic and is currently not harming the environment. </p> <p>The Fire and Rescue team are now trying to flush out the green substance, and said that the incoming rain should help turn the water colour back to normal. </p> <p>Another resident told 9News that they had seen green water in a stormwater drain at Anderson Park, along Clark Road, on Tuesday, before the green colour spread to the bay on Wednesday.</p> <p>Later in the afternoon, a North Sydney Council spokeswoman confirmed that were no major pollutants in the green water: “At this stage our engineers believe the substance is likely to be fluorescein, which is used as a dye for plumbing works. Fluorescein is a non-toxic substance and breaks down with UV light. The green colour is a feature that makes it easy to trace.” </p> <p>Green water was also spotted in Neutral Bay on Wednesday according to another local. </p> <p><em>Image: Nine</em></p>

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