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TGA warns Aussies against using Ivermectin for COVID-19

<div class="body_text redactor-styles redactor-in"> <p>The Therapeutic Goods Administration (TGA) has detected an increase in the amount of a drug called Ivermectin being imported and it warns against the use of this drug for the treatment of COVID-19 as it is untested for this condition.</p> <p>Ivermectin is an anti-parasitic drug which has been shown to be effective in vitro against a broad range of viruses including HIV, dengue, influenza and zika.</p> <p>However, it is not approved for the treatment of COVID-19. In a statement, the TGA said: ‘The Therapeutic Goods Administration (TGA), part of the Department of Health, has detected increased importation and prescribing of Ivermectin for the treatment of COVID-19.’</p> <p>‘The TGA strongly discourages self-medication and self-dosing with Ivermectin for COVID-19 as it may be dangerous to your health.’</p> <p><strong>Even the drug’s manufacturer warns against using it this way</strong></p> <p>Even the drug's manufacturer, Merck Sharp &amp; Dohme (MSD), has urged people not to use the medication to treat COVID-19, warning in a statement saying:</p> <p>"No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies; No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and a concerning lack of safety data in the majority of studies."</p> <p>Despite those urgings, Ivermectin's popularity amongst fringe medical and anti-vaccination groups - and its promotion via the Internet - has seen demand for it increase here in Australia.</p> <p><strong>Ivermectin is often promoted by anti-COVID figures</strong></p> <p>The cheap and common drug is often promoted by anti-COVID vaccination or anti-lockdown figures, such as former Liberal backbencher Craig Kelly and a number of US conservative, fringe campaigners.</p> <p>Ivermectin has been used around the world for years as a treatment for a range of conditions including head lice, parasites, worms and scabies. It is available as a pill, lotion and shampoo.</p> <p>The drug's advocates have pointed to several studies which allegedly show its effectiveness against COVID-19.</p> <p><a rel="noopener" href="https://pubmed.ncbi.nlm.nih.gov/32251768/" target="_blank">Some Australian research</a> indicated Ivermectin could inhibit the virus from replicating within a cell and reported the drug warrants further investigation into the possible benefits for humans. However, this trial was only carried out in a laboratory.</p> <p>Other research found the amounts needed of Ivermectin would not be possible for human and other research said there was <a rel="noopener" href="mailto:https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full" target="_blank">‘conflicting’ evidence</a> as to its benefits.</p> <p>The Cochrane alliance, a global collaboration between scientists to assess clinical research, said the completed studies were "small and few are considered high quality".</p> <p>"We are uncertain about the efficacy and safety of Ivermectin used to treat or prevent COVID‐19," the alliance reported.</p> <p>The TGA has not approved the drug for COVID-19 treatment, saying more investigation was needed.</p> <strong>What’s happening overseas?</strong> <p>In the United States, health authorities have warned people against using doses of Ivermectin.</p> <p>The problem has become noticeable in some states where local health authorities have noticed dramatic increases in poisoning.</p> <p>The Health Department of the US State of Mississippi said 70 per cent of the calls it received recently about poisoning have been related to people taking Ivermectin.</p> <p><em>Photo: Getty Images </em></p> </div>

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The therapeutic benefits of heavy blankets

<p>Have you ever curled up with a thick, heavy blanket and felt a near-instant sense of relief? Perhaps it's been your duvet you've hidden under after a particularly bad day at work, or a quilt you pull out of the closet specifically for wrapping around you during weekend hot chocolates during winter. </p> <p>There's some research that explains why heavy or even weighted blankets are beneficial for sleep and overall mental health. They're an often-used tool by occupational therapists – especially with children – but can be incorporated in anybody's home to help you relax and encourage feelings of calm.</p> <p><strong>Deep pressure touch stimulation</strong></p> <p>The science behind why heavy blankets work is called deep pressure touch stimulation (DPTS). While from a clinical occupational therapy standpoint it has been found that light touch on a person's body can increase tension or alert the system, the opposite can be said for heavy touch. This therapy involves firm pressure, holding, stoking, petting (e.g. of animals).</p> <p>Most of us would have actually received a form of DPTS when we were babies by way of swaddling, which is the practice of wrapping a child tightly in a blanket to restrict movement. This, in turn, can make a baby feel safe and secure, and may help them sleep.</p> <p>The pressure from DPTS works to relax your nervous system, hence being useful for sleep and those that struggling with the symptoms of anxiety at night. Pressure on the body helps generate serotonin which then converts to melatonin, the chemical that tells your system it’s time to rest.</p> <p><strong>Heavy vs. weighted blankets</strong></p> <p>There is actually a difference between a heavy blanket and a weighted blanket, the latter which is usually used in a clinical setting.</p> <p>A heavy blanket may simply be one with a high down or wool content. Think one of those very expensive down duvet inners (they run up to about $900) or, conversely, one of your grandma's ultra-thick war-era woollen blankets.</p> <p>A weighted blanket, available online or <span style="text-decoration: underline;"><strong><a href="https://www.youtube.com/watch?v=svqiyDlJmus&amp;feature=youtu.be" target="_blank">you can sew your own</a></strong></span>, has pellets sewn into quilted pockets to evenly distribute weight. To receive the benefits of a heavy or weighted blanket, it's suggested you seek something that weighs between six and 12 kilograms – generally you want it to be about 10 per cent of your body weight.</p> <p><strong>Are weighted blankets really suitable for children?</strong></p> <p>A review of research by the <em>Journal of Child and Adolescent Psychopharmacology</em> found that weighted blankets can benefit children with behavioural or sensory processing disorders. Children with ADHD and disorders on the autism spectrum have seen detectable levels of calming during DPTS.</p> <p>If you have a neurotypical child, however, they may still benefit. The reports are primarily anecdotal (rather than scientific) but heavy blankets weighing 5-10 per cent of a child's body weight can provide better sleep.</p> <p><strong>Is it safe?</strong></p> <p>According to a paper published in Occupational Therapy and Mental Health, a 12-kilogram blanket when used lying down is safe by all vital sign metrics. This study also found that electrodermal activity (the variation of electrical characteristics on the skin) is reduced by 33 per cent, while 63 percent of users report lower anxiety levels and 78 per cent preferred the blanket as a "calming modality". Other studies have found similar results.</p> <p><strong>Do they really work?</strong></p> <p>However, weighted blankets can't be considered revolutionary from insomnia and anxiety sufferers. The company Gravity, which raised US$3 million <span style="text-decoration: underline;"><strong><a href="https://www.kickstarter.com/projects/1620645203/gravity-the-weighted-blanket-for-sleep-stress-and/description" target="_blank">on its Kickstarter page</a></strong></span> to manufacture its weighted blanket, got into hot water last week after making statements about the benefits of the product that fell out of line with health claims policies.</p> <p>The website, <span style="text-decoration: underline;"><strong><a href="https://www.statnews.com/2017/05/12/gravity-blanket-anxiety-fda/" target="_blank">which has since been changed</a></strong></span>, claimed "the science behind Gravity reveals that it can be used to treat a variety of ailments, including insomnia, post-traumatic stress disorder, obsessive-compulsive disorder, attention deficit hyperactivity disorder, as well as circumstantial stress and prolonged anxiety." </p> <p>This, of course, is an overstatement and blankets have not been shown in studies to "treat" any of these problems, but rather just aid in their symptoms for some people.</p> <p><em>Written by Lee Suckling. First appeared on <a href="http://www.stuff.co.nz/" target="_blank"><strong><span style="text-decoration: underline;">Stuff.co.nz</span></strong></a>.</em></p>

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