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"Of course it's Demi!" World's Most Beautiful Person named for 2025

Demi Moore has been named People magazine’s World’s Most Beautiful Person for 2025, joining the ranks of past honourees like Cindy Crawford, Tom Cruise and Michelle Pfeiffer. At 62, the actress is not only making headlines for her timeless beauty but also for her candid reflections on body image, ageing and self-worth. In an exclusive interview accompanying the annual issue, Moore opened up about her evolving relationship with her body. “I think I've evolved into greater gentility toward myself,” she shared. Admitting that she once had a tendency to "punish" herself, the Ghost star revealed that she's now in a more accepting and appreciative place. “I have a greater appreciation for all that my body has been through that brought me to now,” she said. Though she still experiences moments of insecurity – “It doesn't mean that sometimes I look in the mirror and don't go, 'Oh God, I look old,' or 'Oh, my face is falling' – I do” – Moore said that acceptance has become a key theme in her life. Moore’s resurgence in the spotlight has been bolstered by her acclaimed performance in the 2024 thriller The Substance, alongside Margaret Qualley and Dennis Quaid. The film, which delves into the pressures of ageing in the entertainment industry, drew strong reviews and generated significant Oscar buzz. While she ultimately lost the Academy Award for Best Actress to Mikey Madison, Moore took home her first Golden Globe for the role. In her emotional acceptance speech, she urged the audience to reevaluate how they measure self-worth. “Know the value of your worth,” she said, “by putting down the measuring stick,” drawing cheers from the crowd. With a celebrated career spanning decades, Demi Moore’s new title is not just a recognition of beauty – it’s a tribute to reinvention and the power of self-acceptance. Images: Instagram

Beauty & Style

Remains of 4 Australian soldiers discovered just days ahead of Anzac Day

The remains of four Australian soldiers who perished in World War I have been uncovered in northern France, more than a century after they were killed in the brutal Second Battle of Bullecourt. According to the Australian Department of Defence, the discovery was made during a recent fieldwork operation conducted by the Australian Army’s Unrecovered War Casualties unit. The soldiers were among the thousands who fought in the battle in May 1917, a fierce attempt by the Australian Imperial Force to penetrate the German Hindenburg Line. Up to 10,000 Australian troops were either killed or wounded during the operation, with approximately 3,700 confirmed dead between April and May 1917. Tragically, more than half of these fallen soldiers are believed to lie in unmarked graves across the region. The site of their final stand lies near Villers-Bretonneux, where the Australian National Memorial to the Missing was erected to honour the many who have no known grave. Australian Army Chief Lieutenant General Simon Stuart acknowledged the emotional timing of the find, just days before Anzac Day. “As we approach Anzac Day, recovering these four Australian soldiers reminds us the search for the missing is tireless and ongoing,” Lieutenant General Stuart said. “We do not forget the service and sacrifice of those who serve our nation.” Efforts are now underway to identify the soldiers using forensic analysis and historical research. The Defence Department has vowed to ensure they are reburied with full military honours and the dignity they deserve. The Unrecovered War Casualties unit continues to receive dozens of leads each year regarding the locations of Australian war dead. Discoveries like this are not uncommon: nine soldiers from the Battle of Fromelles were identified in 2018, with another five identified as recently as 2023. More than 44,000 Australians died on the Western Front during World War I, and around 17,000 remain without known graves. This Friday, Australians around the world will pause to reflect at dawn services in honour of the more than 103,000 servicemen and women who have laid down their lives in conflicts past, with the latest discovery serving as a reminder of the war's enduring legacy. Image: Wikimedia Commons

Caring

Cricket world in mourning after passing of Ashes legend

Vale, Keith Stackpole. Australia is in mourning following the passing of the Test cricket great and revered broadcaster, who has died at the age of 84. A giant of the game both on and off the field, Stackpole leaves behind a remarkable legacy as a celebrated Test batter and beloved media figure. A proud Victorian, he represented Australia in 43 Test matches between 1966 and 1974, amassing 2801 runs, including seven centuries. His highest score – an unforgettable 207 against England in Brisbane in 1970 – remains etched in Ashes history. Stackpole made his Test debut in Adelaide in 1966 and went on to play alongside some of the greatest names in Australian cricket, including Ian Chappell and Dennis Lillee. He served as vice-captain and was named Wisden Cricketer of the Year in 1973 – a testament to his skill and leadership. His final Test appearance came in 1974 against New Zealand, where he bowed out with a pair of ducks – a humbling end to a storied career. Not long after, a back injury forced his retirement from the sport, but it was far from the end of his involvement with the game. Stackpole seamlessly transitioned into the media world, becoming a cornerstone of Australian cricket commentary. He was part of Kerry Packer’s groundbreaking World Series Cricket and continued to share his deep knowledge of the game through radio and print, including a long-running newspaper column in Melbourne. His honest insights and affable presence made him a household name beyond the boundary ropes. In 1974, Stackpole was awarded an MBE for his services to cricket – a fitting recognition of his contributions to the sport and to Australian culture. Tributes have poured in from across the cricketing and media worlds. Channel 7 presenter Jim Wilson shared his heartfelt condolences: “Very sad news, loved our catchups and his advice over a coffee and a sanga,” Wilson said. “Always generous with his time, called it the way it was and all our thoughts with Stacky’s family. Vale Keith Stackpole.” Herald Sun journalist Glenn McFarlane also expressed his sorrow: “Incredibly saddened to hear of the passing of the great Keith Stackpole. He was the voice of my childhood on TV and radio, then I was privileged to be one of Stacky’s ‘ghost’ writers for a number of years. Great cricketer; and an absolute gentleman! Condolences to his family.” Stackpole is survived by his wife Pat and children Peter, Tony and Angela. Images: News.com.au / 3AW

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Australia has the highest gambling losses in the world. Is it time for mandatory limits?

<div class="theconversation-article-body">Gambling prevalence studies provide a snapshot of gambling behaviour, problems and harm in our communities. They are typically conducted about every five years. In some Australian states and territories, four or five have been conducted over the past 20 or so years. These have provided a snapshot into how gambling has changed – and how it has not. So, how has gambling in Australia changed in the past two decades or so, and where may we be heading? <blockquote class="twitter-tweet"> Australia has the highest gambling losses in the world. Australia should: 🚫 Ban gambling ads 🎰 Introduce loss limits on pokies and online gambling 📉 Progressively cut the number of pokies in each state Our new report shows how governments should prevent gambling harm.… <a href="https://t.co/7U3IgzOLSp">pic.twitter.com/7U3IgzOLSp</a> — Grattan Institute (@GrattanInst) <a href="https://twitter.com/GrattanInst/status/1831297414080176469?ref_src=twsrc%5Etfw">September 4, 2024</a></blockquote> <h2>The intensification of gambling</h2> In 1997-98, the Productivity Commission found <a href="https://www.pc.gov.au/inquiries/completed/gambling/report/summary.pdf">about 82% of Australians</a> had gambled in the previous 12 months. Almost all further prevalence studies show the proportion of adults gambling has declined substantially over time. The <a href="https://www.gambleaware.nsw.gov.au/resources-and-education/check-out-our-research/published-research/nsw-gambling-survey-2024">2024 NSW prevalence survey</a>, for example, found 54% reported gambling in the previous 12 months, down from 69% in 2006. While fewer people are gambling, the proportion of people experiencing problems has not changed much, <a href="https://www.qgso.qld.gov.au/statistics/theme/society/gambling/australian-gambling-statistics">nor has gambling turnover</a>. In some states, gambling turnover has increased, even when you take inflation into account. So while a smaller proportion of people are gambling, those who do gamble are doing so more frequently, and spend more money – a phenomenon we have described as the “intensification” of the industry. As figures from the Grattan Institute show, the vast majority of gambling spend comes from a very small proportion of people who gamble. <iframe id="Z6EYJ" class="tc-infographic-datawrapper" style="border: 0;" src="https://datawrapper.dwcdn.net/Z6EYJ/" width="100%" height="400px" frameborder="0" scrolling="no"></iframe> <h2>What’s the problem?</h2> Typically, the focus in gambling studies has been on “problem gamblers”, a term we now avoid because it can be stigmatising. This refers to those experiencing severe problems due to their gambling, which is typically <a href="https://www.justice.vic.gov.au/justice-system/safer-communities/gambling/victorian-population-gambling-and-health-study-2023">about 1% of the adult population</a>, and around 2% of people who gamble. This doesn’t sound like much, until you remember 1% of adults in Australia is more than 200,000 people. That’s a lot of people struggling with severe problems. Based on recent prevalence surveys in Australia, these gamblers spend <a href="https://www.gambleaware.nsw.gov.au/resources-and-education/check-out-our-research/published-research/nsw-gambling-survey-2024">about 60 times as much</a> as people who do not experience problems. However, that’s just the most severe cases. <h2>How gambling harms people</h2> When most people think of gambling harm, they think about financial harm. But gambling can cause problems with relationships, work and study, emotional and psychological harm, and <a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-2747-0">even cause health issues</a>. Some degree of gambling harm is experienced by <a href="https://www.gambleaware.nsw.gov.au/resources-and-education/check-out-our-research/published-research/nsw-gambling-survey-2024">around 10-15%</a> of people who gamble. Some groups are overrepresented: young men typically experience very high levels of harm compared to others. Other overrepresented groups are: <ul> <li>those who have not completed tertiary education</li> <li>people who speak a language other than English</li> <li>people who identify as Aboriginal or Torres Strait Islander.</li> </ul> Harm isn’t just experienced by people who gamble, though – it impacts the people around them. While young men are more likely to experience harm from their own gambling, <a href="https://www.gambleaware.nsw.gov.au/resources-and-education/check-out-our-research/published-research/nsw-gambling-survey-2024">women, particularly young women</a>, are most likely to experience harm from someone else’s gambling. When we take all of these sources of harm into account, we get a much better picture of gambling harm in our community: <a href="https://www.gambleaware.nsw.gov.au/resources-and-education/check-out-our-research/published-research/nsw-gambling-survey-2024">around 15-20% of all adults</a> (not all gamblers) experience harm. That’s very different to the figure of 1% we’ve focused on in the past. We’re still missing some accounting, though: we don’t know how much harm is experienced by people under 18, for example, because prevalence studies typically only include adults. <h2>Where does the harm come from?</h2> The most problematic form in Australia is pokies, responsible for <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10260219/#:%7E:text=EGMs%20are%20responsible%20for%2051,problems%20due%20to%20low%20participation.">about 51-57% of problems</a>. Casinos are responsible for <a href="https://ftp.justice.vic.gov.au/justice-system/safer-communities/gambling/victorian-population-gambling-and-health-study-2023">another 10-14%</a>, although fewer people have been gambling in casino games in recent years. Sports betting and race betting together account for about another 19-20% of harm. Between them, pokies, casino games and sports and race betting account for about 90% of harm to Australian gamblers. <iframe id="w2wEY" class="tc-infographic-datawrapper" style="border: 0;" src="https://datawrapper.dwcdn.net/w2wEY/" width="100%" height="400px" frameborder="0" scrolling="no"></iframe> <h2>Availability is an issue</h2> This widespread availability of pokies is the biggest single driver behind gambling harm in Australia. <iframe id="hIgeD" class="tc-infographic-datawrapper" style="border: 0;" src="https://datawrapper.dwcdn.net/hIgeD/" width="100%" height="400px" frameborder="0" scrolling="no"></iframe> In other countries, pokies are limited to venues that are specifically used for gambling, like casinos or betting shops. We have pokies in a huge number of our pubs and clubs, except in Western Australia. A couple of years ago, we used national prevalence data to compare gambling problems in WA <a href="https://akjournals.com/view/journals/2006/12/3/article-p721.xml">to the rest of the country</a>. A higher percentage of adults in WA gamble, but mostly on the lotteries which are typically <a href="https://theconversation.com/pokies-lotto-sports-betting-which-forms-of-problem-gambling-affect-australians-the-most-240665">not associated with much harm</a>. Gambling on pokies is far less prevalent in WA because they’re only available in one casino. Gambling problems and harm are about one-third lower in WA, and our analysis shows this can be attributed to the limited access to pokies. This also tells us something important. If pokies are not available, people will typically not substitute them with other harmful forms. It points to the role of the availability of dangerous gambling products in gambling harm, rather than personal characteristics. Online gambling has also become a lot more available. Most of us now have a mobile phone almost surgically implanted onto our hand, making online gambling more accessible than ever. Not surprisingly, <a href="https://www.gamblingresearch.org.au/publications/second-national-study-interactive-gambling-australia-2019-20">online gambling continues to increase</a>. <h2>An obvious solution to try</h2> Governments have taken increasingly proactive measures to help address gambling harm, such as the <a href="https://www.dss.gov.au/gambling/resource/national-consumer-protection-framework-online-wagering-national-policy-statement">National Consumer Protection Framework for Online Gambling</a>, strategies for minimising harm such as NSW’s investment into <a href="https://www.nsw.gov.au/media-releases/gambleaware-week-0">gambling harm minimisation</a>, Victoria’s <a href="https://www.theguardian.com/australia-news/2024/nov/26/victoria-pokies-changes-limits-new-laws">proposed reforms on pokies</a> including mandatory precommitment limits, Queensland’s <a href="https://www.publications.qld.gov.au/dataset/gambling-harm-min/resource/84d444db-97e0-4be0-8e87-0c6f0cb412d6">Gambling Harm Minimisation Plan</a> and the ACT’s <a href="https://www.gamblingandracing.act.gov.au/__data/assets/pdf_file/0009/1436580/Strategy-for-gambling-harm-prevention.pdf">Strategy for Gambling Harm Prevention</a>. Voluntary limits have been trialled to help people keep their gambling under control, but have had <a href="https://www.abc.net.au/news/2024-12-03/nsw-government-cashless-gaming-trial-findings-released/104679384">virtually no uptake</a>. For example, the recent <a href="https://www.liquorandgaming.nsw.gov.au/__data/assets/pdf_file/0018/1340136/evaluation-of-the-nsw-digital-gaming-wallet-trial-2024.pdf">NSW Digital Gaming Wallet trial</a> was conducted in 14 venues. Only 32 people were active users, and 14 of these were deemed genuine users. <a href="https://www.adelaide.edu.au/saces/ua/media/652/evaluation-of-yourplay-final-report_0.pdf">Another study</a> found only 0.01% of all money put through machines in Victoria used the voluntary YourPlay scheme. The problem with voluntary limits is, no one volunteers. Mandatory limits though are almost certainly necessary, just like we have mandatory limits for how fast you can drive, or how much you can drink before the bartender puts you in a taxi. There will almost certainly be push back against this, just like the introduction of mandatory seatbelts in the 1970s, or <a href="https://www.abc.net.au/news/2023-10-04/road-safety-history-australia-toll-increase/102903364">the introduction of random breath testing</a>. Now, we accept them as important public health measures. History tells us the same will happen with mandatory gambling limits, even if we’re a bit uncomfortable about it at first.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/252389/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> By <a href="https://theconversation.com/profiles/alex-russell-133860">Alex Russell</a>, Principal Research Fellow, <a href="https://theconversation.com/institutions/cquniversity-australia-2140">CQUniversity Australia</a>; <a href="https://theconversation.com/profiles/matthew-browne-97705">Matthew Browne</a>, Senior Lecturer in Statistics, <a href="https://theconversation.com/institutions/cquniversity-australia-2140">CQUniversity Australia</a>, and <a href="https://theconversation.com/profiles/matthew-rockloff-569">Matthew Rockloff</a>, Head, Experimental Gambling Research Lab, <a href="https://theconversation.com/institutions/cquniversity-australia-2140">CQUniversity Australia</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/gambling-in-australia-how-bad-is-the-problem-who-gets-harmed-most-and-where-may-we-be-heading-252389">original article</a>. Image: Shutterstock </div>

Money & Banking

Pope Francis' cause of death and burial wishes revealed

The Vatican has confirmed that Pope Francis died from a stroke followed by heart failure, according to an official statement released by the Vatican press office. The 88-year-old pontiff passed away on Easter Monday, April 21, with underlying health conditions also contributing to his death. In a statement signed by Andrea Arcangeli, Director of the Health and Hygiene Directorate of the Vatican City State, the Vatican revealed that Francis had suffered a previous episode of acute respiratory failure, along with arterial hypertension and type II diabetes. Pope Francis made his final public appearance on Easter Sunday, where he delivered a brief Easter blessing to thousands gathered in St Peter’s Square. Unable to finish reading his address, the ailing pope sat as an aide delivered the rest of the speech, which called for peace in war-torn regions such as Gaza, Ukraine and Sudan. Following his death, the Vatican also made public the burial wishes outlined in the pope’s will. Francis requested a simple burial in the ground at Rome’s Basilica di Santa Maria Maggiore – marked only with the Latin inscription Franciscus. This will be the first time in over a century that a pope will be buried outside the Vatican. According to the will, an anonymous benefactor has agreed to cover the costs of his burial. With the pontiff’s passing, the Catholic Church now enters a traditional period of mourning known as the Novendiales, lasting nine days. During this time, Pope Francis will lie in state as preparations for his funeral are made. The conclave – the sacred process to elect a new pope – is expected to begin no sooner than 15 days and no later than 20 days following his death. Pope Francis, born Jorge Mario Bergoglio, became the first pope from the Americas and the first Jesuit pope. His death marks the end of a papacy defined by humility, progressive stances and a deep focus on global humanitarian issues. Images: Wikimedia Commons

Caring

A simple, science-backed way to sharpen thinking and improve memory – and it's not what you think

<div class="theconversation-article-body">Many of us turn to Sudoku, Wordle or brain-training apps to sharpen our minds. But research is increasingly showing one of the best ways to boost memory, focus and brain health is exercise. Our <a href="https://bjsm.bmj.com/content/early/2025/03/06/bjsports-2024-108589">new research</a> reviewed data from more than 250,000 participants across 2,700 studies. We found exercise helps boost brain function – whether it’s walking, cycling, yoga, dancing, or even playing active video games such as Pokémon GO. Moving your body improves how we think, make decisions, remember things and stay focused – no matter your age. <h2>What the science says</h2> Our review adds to a growing body of research that shows regular physical activity <a href="https://bjsm.bmj.com/content/early/2025/03/06/bjsports-2024-108589">improves</a> three key areas of brain function: <ul> <li> cognition, which is your overall ability to think clearly, learn and make decisions </li> <li> memory, especially short-term memory and the ability to remember personal experiences </li> <li> executive function, which includes focus, planning, problem-solving and managing emotions. </li> </ul> We conducted an umbrella review, which means we looked at the results of more than 130 high-quality research reviews that had already combined findings from many exercise studies. These studies usually involved people starting a new, structured exercise program, not just tracking the exercise they were already doing. To assess the effects on cognition, memory and executive function, the original studies used a range of brain function tests. These included things like remembering word lists, solving puzzles, or quickly switching between tasks – simple activities designed to reliably measure how well the brain is working. The improvements were small to moderate. On average, exercise led to a noticeable boost in cognition, with slightly smaller but still meaningful gains in memory and executive function. The benefits showed up across all age groups, though children and teens saw major gains in memory. People with attention-deficit hyperactivity disorder (ADHD) showed greater improvements in executive function after physical activity than other population groups. The brain started responding fairly quickly – many people experienced improvements after just 12 weeks of starting regular exercise. Generally, the greatest benefits were seen in those doing at least 30 minutes of exercise on most days of the week, aiming for a total of about 150 minutes per week. <h2>What’s happening in the brain?</h2> Activities such as walking or cycling can <a href="https://www.pnas.org/doi/abs/10.1073/pnas.1015950108">increase the size of the hippocampus</a>, the part of the brain responsible for memory and learning. In <a href="https://www.pnas.org/doi/full/10.1073/pnas.1015950108">one study</a>, older adults who did aerobic exercise for a year grew their hippocampus by 2%, effectively reversing one to two years of age-related brain shrinkage. More intense workouts, such as running or high-intensity interval training, can further <a href="https://onlinelibrary.wiley.com/doi/full/10.1155/2017/8305287">boost neuroplasticity</a> – the brain’s ability to adapt and rewire itself. This helps you learn more quickly, think more clearly and stay mentally sharp with age. <h2>Another reason to get moving</h2> The world’s population is ageing. By 2030, <a href="https://www.who.int/news-room/fact-sheets/detail/ageing-and-health">one in six of people will be aged over 60</a>. With that comes a rising risk of dementia, Alzheimer’s disease and cognitive decline. At the same time, many adults aren’t moving enough. One in three adults <a href="https://www.who.int/news-room/fact-sheets/detail/physical-activity">aren’t meeting the recommended levels</a> of physical activity. Adults <a href="https://www.who.int/initiatives/behealthy/physical-activity">should aim for</a> at least 150 of moderate exercise – such as brisk walking – each week, or at least 75 minutes of more vigorous activity, like running. It’s also important to incorporate muscle-strengthening exercises, such as lifting weights, into workouts at least twice a week. <h2>Everyday movement counts</h2> You don’t need to run marathons or lift heavy weights to benefit. Our study showed lower-intensity activities such as yoga, tai chi and “exergames” (active video games) can be just as effective – sometimes even more so. These activities engage both the brain and body. Tai chi, for instance, requires focus, coordination and memorising sequences. Exergames often include real-time decision-making and rapid response to cues. This trains attention and memory. Importantly, these forms of movement are inclusive. They can be done at home, outdoors, or with friends, making them a great option for people of all fitness levels or those with limited mobility. Although you may already be doing a lot through daily life – like walking instead of driving or carrying shopping bags home – it’s still important to find time for structured exercise, such as lifting weights at the gym or doing a regular yoga class, to get the full benefits for your brain and body. <h2>Real-life applications</h2> If you’re a grandparent, consider playing Wii Sports virtual tennis or bowling with your grandchild. If you’re a teenager with signs of ADHD, try a dance class, and see if it impacts your concentration in class. If you’re a busy parent, you might be more clear-headed if you can squeeze a 20-minute yoga video session between meetings. In each of these cases, you’re not just being active, you’re giving your brain a valuable tune-up. And unlike most brain-training apps or supplements, exercise delivers far reaching benefits, including improved <a href="https://www.sciencedirect.com/science/article/pii/S1389945721002914?casa_token=pXaOJcQJ7d0AAAAA:0i4BjaxqJ21AQ2bGXI4DfQ6twKNybrg7c2f0_Xs7t-hWyDOH0SuKGTfruy-JlC_rMokUM3iWdlSQ">sleep</a> and <a href="https://bjsm.bmj.com/content/57/18/1203">mental health</a>. Workplaces and schools are starting to take note. <a href="https://onlinelibrary.wiley.com/doi/10.1002/smi.2654">Short movement breaks</a> are being introduced during the workday to improve employee focus. Schools that incorporate <a href="https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-017-0569-9">physical activity</a> into the classroom are seeing improvements in students’ attention and academic performance. Exercise is one of the most powerful and accessible tools we have for supporting brain health. Best of all, it’s free, widely available and it’s never too late to start.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/253751/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> By <a href="https://theconversation.com/profiles/ben-singh-1297213">Ben Singh</a>, Research Fellow, Allied Health & Human Performance, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a> and <a href="https://theconversation.com/profiles/ashleigh-e-smith-201327">Ashleigh E. Smith</a>, Associate Professor, Healthy Ageing, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/heres-a-simple-science-backed-way-to-sharpen-your-thinking-and-improve-your-memory-253751">original article</a>. Image: Shutterstock </div>

Mind

"Absolutely stunning!": Jelena Dokic wows fans with new look

Former tennis star Jelena Dokic has debuted a striking new look, showcasing her dramatic weight loss and inspiring thousands with her message of self-love. The 41-year-old, once ranked world No. 4, made a radiant return to the spotlight as part of Channel 9’s coverage of the Billie Jean King Cup. A photo from the broadcast set quickly sparked an outpouring of support from fans, celebrating not just her transformation, but her ongoing role as a symbol of strength and positivity. “Back in the studio and back doing the tennis and TV with my @channel9 @wwos family,” Dokic shared with her 285,000 Instagram followers on Thursday. “Nice little lead into the next 3 grand slams of the year with a @billiejeankingcup week.” Supportive messages flooded the post, with fans praising her radiant presence. “You’re a dead set LEGEND Jelena,” one admirer wrote, while another added, “Absolutely stunning!” <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/DIQMMW5pIcp/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/DIQMMW5pIcp/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by JELENA DOKIC 🇦🇺🇦🇺🇦🇺 (@dokic_jelena)</a> </div> </blockquote> Dokic has been open about her personal struggles, candidly discussing her battles with mental health, weight challenges and online bullying. In a heartfelt Instagram post from March 11, she reflected on her journey, using side-by-side images to convey a powerful message about body image. “What is the difference between the two images?” she asked. “Nothing except what you see on the outside, my BODY SIZE. I am the same hardworking person, respectful, generous, empathetic, compassionate, humble, kind, driven, strong, resilient, capable and loving person, woman and friend.” She continued, urging her followers to look beyond appearances: “Beauty has nothing to do with looks. It’s how you are as a person. It’s how you make others feel especially about themselves. No beauty shines brighter than that of a kind heart.” Now thriving as an author, expert tennis commentator and vocal advocate for mental health and body positivity, Dokic continues to inspire others with her authenticity and courage. Her documentary Unbreakable, which aired on Channel 9 earlier this year after its successful cinematic release in December 2024, has been met with rave reviews for its raw and honest portrayal of her life and career. Image: Instagram

Body

Hollywood legend reveals secret cancer battle

Hollywood icon Anjelica Huston has opened up for the first time about her private battle with cancer, revealing she was diagnosed back in 2019 but is now celebrating four years of being cancer-free. The Oscar-winning actress, 73, shared that the diagnosis came as a “big shock” shortly after the release of John Wick: Chapter 3 – Parabellum, in which she starred alongside Keanu Reeves and Halle Berry. While Huston chose not to disclose the exact type of cancer she faced, she expressed pride in overcoming the illness and praised her medical team for their care. “It came as a big shock, but it made me conscious of what I shouldn’t do, of places I shouldn’t go,” Huston told People magazine. “Sometimes you feel like you don't want to talk about it for the obvious reasons, but there's a lot to be said for talking about it and getting it out there and celebrating the fact that one's come through.” Reflecting on her journey, she added, “I managed to survive it, and I’m proud of myself.” Huston, best known for her roles in The Addams Family, The Witches, and Prizzi's Honor, comes from a legendary Hollywood lineage. She is the daughter of famed director and screenwriter John Huston and the granddaughter of Canadian star Walter Huston. Several of her siblings have also pursued acting careers. Her personal life has also captured public interest over the years. Huston famously dated actor Jack Nicholson, describing their relationship as an "emotional rollercoaster." In 1992, she married sculptor Robert Graham, who sadly passed away in 2008. Now, with her cancer battle behind her, Huston is embracing life with renewed appreciation and strength, inspiring fans worldwide. Images: Instagram

Caring

Princess Diana’s largest-ever wardrobe auction set to dazzle the world

Get ready for royal fashion history to be rewritten... This June, the largest collection of clothing ever owned by Diana, Princess of Wales, will hit the auction block – and it promises to be nothing short of spectacular. Julien's Auctions, the house behind this extraordinary event, has announced that over 200 breathtaking pieces will go under the hammer, many of which have never been seen by the public before. From the timeless elegance of Princess Diana to the grandeur of the Duke and Duchess of Windsor, plus historic treasures from Queen Elizabeth II, the Queen Mother, and even royal heirlooms dating back to the 19th century – this auction is shaping up to be a once-in-a-lifetime event. Fittingly titled <a href="https://www.juliensauctions.com/en/auctions/princess-diana-s-style-a-royal-collection" target="_blank" rel="noopener">"Princess Diana's Style & A Royal Collection"</a>, the auction will unfold at the glamorous Peninsula Beverly Hills on June 26. According to Julien’s, the sale offers fans and collectors a rare and intimate chance to own a piece of history and connect with Diana’s iconic style legacy. "Princess Diana holds a special place in the heart of Julien's Auctions, and we are honoured to continue to preserve her legacy," shared Martin Nolan, co-founder and executive director of Julien's. "This collection is the most significant offering of her wardrobe ever presented at auction – each item a window into a moment in history and a tribute to a woman whose humility, style, and personal warmth continue to inspire the world." Among the crown jewels of the collection is the charming 1988 Bellville Sassoon floral day dress, affectionately known as Diana’s "caring dress." The late princess famously wore this bright, cheerful ensemble during hospital visits and engagements with children, knowing its joyful print would lift spirits. Diana even skipped the matching hat, saying, "You couldn't cuddle a child in a hat." While Julien’s is keeping the full list of auction items under wraps for now, excitement is mounting. Some pieces originally featured in Diana’s legendary 1997 Christie's auction – which raised an astounding $5 million for charity – will make an encore appearance. Before the big day, the dazzling collection will go on display in museums in Seattle and Ireland, giving fans worldwide the chance to admire these royal treasures up close. The auction follows a streak of record-breaking sales for Diana’s wardrobe. In 2023, her unforgettable ballerina-length black and blue evening gown by Jacques Azagury fetched a staggering $1.4 million, shattering records at 11 times its estimate. And let’s not forget her beloved emerald green Kurt Geiger shoes, which sold for an eye-watering $693,000. Perhaps most astonishing of all: Diana's famous sheep-print jumper by Warm and Wonderful, which leapt to an incredible $1.7 million at auction last year – a jaw-dropping 14 times its expected price. Image: <span style="background-color: #ffffff; color: #2c3338; font-family: -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen-Sans, Ubuntu, Cantarell, 'Helvetica Neue', sans-serif; font-size: 14px; white-space-collapse: preserve-breaks;">Julien's Auctions

Beauty & Style

Cause of fatal Sea World chopper crash finally revealed

A catastrophic combination of radio failure and limited visibility led to the tragic mid-air collision of two Sea World helicopters on the Gold Coast in January 2023, a final investigation report has revealed. The Australian Transport Safety Bureau (ATSB) released its long-awaited findings on Wednesday, more than two years after the accident that claimed four lives and left nine others injured at the height of the summer holiday season. According to the report, a critical inbound taxiing call from one helicopter, which was carrying five passengers, failed to transmit to a second helicopter preparing for takeoff with six people aboard. Investigators determined that a fault in the antenna of the first helicopter, VH-XKQ, prevented the transmission, despite the pilot having made the call. The faulty antenna had been an issue for several days prior to the crash. While the ground crew had earlier advised that the airspace was clear, by the time the second helicopter lifted off, that advice was no longer valid. The first helicopter had been waiting for a taxi call from the second chopper to ensure safe separation, but the call never came. “Neither pilot was aware of the existence of faults in the radio of VH-XKQ that likely prevented broadcast of the taxi call,” the ATSB report stated. Without functioning radio communications, neither pilot could pinpoint the location of the other aircraft, contributing to the fatal collision. The investigation also identified limited visibility from both helicopters and the pilots’ divided attention – focused partly on boat traffic and other aircraft in the area – as additional contributing factors. Sea World Helicopters’ safety systems, including radio calls, hand signals, and visual warning devices, were found to be inadequate. These shortcomings led both pilots to incorrectly assess the position of the other helicopter. Further compounding the tragedy, the ATSB found evidence that some passengers were improperly restrained, although it could not determine how this affected the severity of their injuries. The report also highlighted operational changes leading up to the crash. A week before the incident, the helicopters were swapped, and a year earlier, the helipads had been relocated – both changes that contributed to a breakdown in safety protocols and increased collision risk. The new aircraft lacked internal company radios, had no live traffic displays, and the pilots were unfamiliar with the systems, the report noted. The collision claimed the lives of pilot Ashley Jenkinson, 40, British tourists Ron and Diane Hughes, aged 65 and 57, and Sydney mother Vanessa Tadros, 36. Tadros’ 10-year-old son Nicholas survived but required extensive surgeries. Victorian mother Winnie de Silva, 33, and her nine-year-old son Leon were also hospitalised with serious injuries. Michael James, the pilot of the second helicopter, managed to execute an emergency landing despite suffering injuries from shattered glass. He passed away in June 2024 after a battle with cancer. The findings come as Shine Lawyers, representing several victims and families affected by the crash, prepare for civil proceedings. Claims of up to $925,000 per person have been lodged against Sea World Helicopters, and the release of the ATSB report is expected to inform further legal action. “This was such a profoundly unnecessary loss of life which must be prosecuted fully to ensure it never happens again,” said litigation specialist Roger Singh. “We will examine the findings of this report with a view to identifying other potential defendants and further damages which may be sought.” Images: ATSB

Legal

A new COVID variant is on the rise: what you need to know

<div class="theconversation-article-body"> More than five years since COVID was <a href="https://www.who.int/europe/emergencies/situations/covid-19">declared a pandemic</a>, we’re still facing the regular emergence of new variants of the virus, SARS-CoV-2. The latest variant on the rise is LP.8.1. It’s <a href="https://www.health.gov.au/resources/collections/australian-respiratory-surveillance-reports-2025">increasing in Australia</a>, making up close to <a href="https://www.health.nsw.gov.au/Infectious/covid-19/Documents/respiratory-surveillance-20250322.pdf">one in five COVID cases</a> in New South Wales. Elsewhere it’s become even more dominant, comprising at least three in five cases <a href="https://inews.co.uk/news/health/lp-covid-variant-cases-future-waves-3598768">in the United Kingdom</a>, for example. So what is LP.8.1? And is it cause for concern? Let’s look at what we know so far. <h2>An offshoot of Omicron</h2> LP.8.1 was first <a href="https://www.who.int/publications/m/item/risk-evaluation-for-sars-cov-2-variant-under-monitoring-lp81">detected in July 2024</a>. It’s a descendant of Omicron, specifically of KP.1.1.3, which is descended from <a href="https://theconversation.com/the-emergence-of-jn-1-is-an-evolutionary-step-change-in-the-covid-pandemic-why-is-this-significant-220285">JN.1</a>, a subvariant that caused large waves of COVID infections around the world in late 2023 and early 2024. The <a href="https://www.who.int/activities/tracking-SARS-CoV-2-variants">World Health Organization</a> (WHO) designated LP.8.1 as a <a href="https://www.who.int/publications/m/item/risk-evaluation-for-sars-cov-2-variant-under-monitoring-lp81">variant under monitoring</a> in January. This was in response to its significant growth globally, and reflects that it has genetic changes which may allow the virus to spread more easily and pose a greater risk to human health. Specifically, LP.8.1 has mutations at six locations in its spike protein, the protein which allows SARS-CoV-2 to attach to our cells. One of these mutations, V445R, is thought to allow this variant to spread more easily relative to other circulating variants. V445R has been shown to increase binding to human lung cells in <a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00015-5/fulltext">laboratory studies</a>. <figure class="align-center "><img src="https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=45&auto=format&w=600&h=468&fit=crop&dpr=1 600w, https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=30&auto=format&w=600&h=468&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=15&auto=format&w=600&h=468&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=45&auto=format&w=754&h=588&fit=crop&dpr=1 754w, https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=30&auto=format&w=754&h=588&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/658901/original/file-20250401-56-eywcgb.png?ixlib=rb-4.1.0&q=15&auto=format&w=754&h=588&fit=crop&dpr=3 2262w" alt="A chart showing the distribution of different COVID variants in different colours." /><figcaption>The proportion of COVID cases caused by LP.8.1 has been rising in New South Wales. <a class="source" href="https://www.health.nsw.gov.au/Infectious/covid-19/Documents/respiratory-surveillance-20250322.pdf">NSW Health</a></figcaption></figure> Notably, the symptoms of LP.8.1 don’t appear <a href="https://www.who.int/publications/m/item/risk-evaluation-for-sars-cov-2-variant-under-monitoring-lp81">to be any more severe</a> than other circulating strains. And the WHO has evaluated the additional public health risk LP.8.1 poses at a global level to be low. What’s more, LP.8.1 remains a variant under monitoring, rather than a variant of interest or a variant of concern. In other words, these changes to the virus with LP.8.1 are small, and not likely to make a big difference to the trajectory of the pandemic. <h2>That doesn’t mean cases won’t rise</h2> COVID as a whole is still a major national and international health concern. So far this year there have been close to <a href="https://www.health.gov.au/resources/collections/australian-respiratory-surveillance-reports-2025">45,000 new cases recorded in Australia</a>, while around <a href="https://covidlive.com.au/report/daily-hospitalised/aus">260 people are currently in hospital</a> with the virus. Because many people are no longer testing or reporting their infections, the real number of cases is probably far higher. In <a href="https://www.health.gov.au/resources/collections/australian-respiratory-surveillance-reports-2025">Australia</a>, LP.8.1 has become the <a href="https://www.health.nsw.gov.au/Infectious/covid-19/Documents/respiratory-surveillance-20250322.pdf">third most dominant strain in NSW</a> (behind <a href="https://theconversation.com/xec-is-now-in-australia-heres-what-we-know-about-this-hybrid-covid-variant-239292">XEC</a> and KP.3). It <a href="https://www.health.nsw.gov.au/Infectious/covid-19/Documents/respiratory-surveillance-20250322.pdf">has been growing</a> over the past couple of months and this trend looks set to continue. This is not to say it’s not growing similarly in other states and territories, however NSW Health publishes <a href="https://www.health.nsw.gov.au/Infectious/covid-19/Pages/reports.aspx">weekly respiratory surveillance</a> with a breakdown of different COVID variants in the state. Sequences of LP.8.1 in the <a href="https://gisaid.org/">GISAID database</a>, used to track the prevalence of variants around the world, increased from <a href="https://www.who.int/publications/m/item/risk-evaluation-for-sars-cov-2-variant-under-monitoring-lp81">around 3%</a> at the end of 2024 to 38% of global sequences as of <a href="https://x.com/Mike_Honey_/status/1905816340331728914">mid March</a>. In some countries it’s climbed particularly high. In the United States LP.8.1 is responsible for <a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions">55% of cases</a>. In <a href="https://inews.co.uk/news/health/lp-covid-variant-cases-future-waves-3598768">the UK</a>, where LP.8.1 is making up at least 60% of cases, scientists fear <a href="https://inews.co.uk/news/science/new-covid-wave-cases-hospitalisations-3611459?srsltid=AfmBOor_V7pQrPMPhUYQA2KCZgRfsI_CpxTwIRiHDFJHIJhq2kbAmD42">it may be driving a new wave</a>. <h2>Will COVID vaccines work against LP.8.1?</h2> Current COVID vaccines, including the most recently available <a href="https://theconversation.com/new-covid-vaccines-may-be-coming-to-australia-heres-what-to-know-about-the-jn-1-shots-237652">JN.1 shots</a>, are still expected to <a href="https://www.who.int/publications/m/item/risk-evaluation-for-sars-cov-2-variant-under-monitoring-lp81">offer good protection</a> against symptomatic and severe disease with LP.8.1. Nonetheless, due to its designation as a variant under monitoring, WHO member countries will continue to study the behaviour <a href="https://www.who.int/publications/m/item/risk-evaluation-for-sars-cov-2-variant-under-monitoring-lp81">of the LP.8.1 variant</a>, including any potential capacity to evade our immunity. While there’s no cause for panic due to LP.8.1 variant at this stage, COVID can still be a severe disease for some. Continued vigilance and vaccination, particularly <a href="https://www.health.gov.au/our-work/covid-19-vaccines/getting-your-vaccination">for medically vulnerable groups</a>, is essential in minimising the impact of the disease.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/253237/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> By <a href="https://theconversation.com/profiles/thomas-jeffries-1511629">Thomas Jeffries</a>, Senior Lecturer in Microbiology, <a href="https://theconversation.com/institutions/western-sydney-university-1092">Western Sydney University</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/a-new-covid-variant-is-on-the-rise-heres-what-to-know-about-lp-8-1-253237">original article</a>. Image: Shutterstock </div>

Caring

Incredible new pacemaker tinier than a grain of rice

Engineers from Northwestern University in the US have developed a groundbreaking pacemaker so tiny that it can fit inside the tip of a syringe – is smaller than a grain of rice – and be non-invasively injected into the body. This innovation could revolutionise cardiac care by offering a minimally invasive alternative to traditional pacemakers. "We have developed what is, to our knowledge, the world's smallest pacemaker," said bioelectronics pioneer John A Rogers, who led the development. The small, wireless device is biocompatible and designed to be gradually broken down and absorbed by the body, reducing the need for surgical extraction. Rogers and his colleagues tested the effectiveness of their tiny, temporary pacemaker in human heart tissue and animal models. Measuring just 1.8mm by 3.5mm by 1mm, the device is smaller than any previously reported pacemaker. It is paired with a soft, flexible, wireless wearable device mounted on a patient’s chest, which controls the pacing. When an irregular heartbeat is detected, the wearable device emits a light pulse that penetrates through the skin, breastbone and muscles to activate the pacemaker and regulate heart rhythm. While designed to work for hearts of all sizes, the pacemaker is particularly well-suited for newborns with congenital heart defects. Northwestern experimental cardiologist Igor Efimov, who co-led the study, said this device could play a critical role in the effective treatment of infants. "Our major motivation was children," Efimov explained. "About 1 percent of children are born with congenital heart defects, regardless of whether they live in a low-resource or high-resource country. The good news is that these children only need temporary pacing after surgery. In about seven days or so, most patients’ hearts will self-repair. But those seven days are absolutely critical." Researchers believe this pacemaker could provide a safer alternative to traditional pacemakers for temporary pacing in patients with bradycardia, a condition characterised by a resting heart rate below 60 beats per minute. Additionally, they suggest that the technology’s versatility could extend to broader medical applications in bioelectronic medicine, such as aiding nerve and bone healing and blocking pain. This revolutionary development represents a significant step forward in cardiac treatment, potentially improving outcomes for both infants and adults requiring temporary heart pacing. Images: Northwestern University

Body

Do stem cell injections for knee osteoarthritis actually work?

<div class="theconversation-article-body">More than 500 million people around the world <a href="https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(23)00163-7/fulltext">live with osteoarthritis</a>. The knee is affected more often than any other joint, with symptoms (such as pain, stiffness and reduced movement) affecting work, sleep, sport and <a href="https://www.aihw.gov.au/reports/chronic-musculoskeletal-conditions/osteoarthritis">daily activities</a>. Knee osteoarthritis is often thought of as thinning of the protective layer of cartilage within the joint. But we now understand it affects all the structures of the joint, including the bones, muscles and nerve endings. While there are things that <a href="https://www.safetyandquality.gov.au/standards/clinical-care-standards/osteoarthritis-knee-clinical-care-standard/information-consumers-osteoarthritis-knee-clinical-care-standard">can be done to manage</a> the symptoms of knee osteoarthritis, there is no cure, and many people experience persistent pain. As a result, an opportunity exists for <a href="https://www.rheuma.com.au/stem-cell-therapy-good-bad-ugly/174">as yet unproven treatments</a> to enter the market, often before regulatory safeguards can be put in place. Stem cell injections are one such treatment. A <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013342.pub2">new review</a> my colleagues and I published this week finds that evidence of their benefits and harms remains elusive. <h2>Stem cell treatments</h2> Stem cells are already established as treatments for some diseases – <a href="https://www.lymphoma.org.au/lymphoma/treatments/stem-cell-transplants/autologous-stem-cell-transplant/">mostly disorders of the blood</a>, bone marrow or immune system – which has led to suggestions they could be used for a much wider array of conditions. Stem cells have been touted as promising treatments for osteoarthritis because they have special properties which allow them to replicate and develop into the mature healthy cells that make up our body’s organs and other tissues, including cartilage. Stem cell treatments for osteoarthritis generally involve <a href="https://www.aboutstemcells.org/treatments">taking a sample of tissue</a> from a site that is rich in stem cells (such as bone marrow or fat), treating it to increase the number of stem cells, then injecting it into the joint. The hope is that if the right type of stem cells can be introduced into an osteoarthritic joint in the right way and at the right time, they may help to repair damaged structures in the joint, or have other effects such as reducing inflammation. But no matter how convincing the theory, we need good evidence for effectiveness and safety before a new therapy is adopted into practice. Stem cell injections have not been approved by Australia’s <a href="https://www.tga.gov.au/news/news/stem-cell-treatments-and-regulation-quick-guide-consumers#:%7E:text=Does%20the%20TGA%20regulate%20stem,does%20not%20regulate%20medical%20practice">Therapeutic Goods Administration</a> for the treatment of osteoarthritis. Nonetheless, some clinics in Australia and around the world still offer them. Because of the regulatory restrictions, we don’t have reliable numbers on how many procedures are being done. They’re not covered by Medicare, so the procedure can cost the consumer thousands of dollars. And, as with any invasive procedure, both the <a href="https://coroners.nsw.gov.au/documents/findings/2016/Findings%20Drysdale.pdf">harvest of stem cells</a> and the joint injection procedure may carry the potential for harm, such as infection. <h2>What we found</h2> Our <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013342.pub2">new review</a>, published by the independent, international group the Cochrane Collaboration, looks at all 25 randomised trials of stem cell injections for knee osteoarthritis that have been conducted worldwide to date. Collectively, these studies involved 1,341 participants. We found stem cell injections may slightly improve pain and function compared with a placebo injection, but the size of the improvement may be too small for the patient to notice. The evidence isn’t strong enough to determine whether there is any improvement in quality of life following a stem cell injection, whether cartilage regrows, or to estimate the risk of harm. This means we can’t confidently say yet whether any improvement that might follow a stem cell injection is worth the risk (or the cost). <h2>Hope or hype?</h2> It’s not surprising we invest hope in finding a transformative treatment for such a common and disabling condition. Belief in the benefits of stem cells is widespread – more than <a href="https://www.arthroscopyjournal.org/article/S0749-8063(21)00571-5/abstract">three-quarters of Americans</a> believe stem cells can relieve arthritis pain and more than half believe this treatment to be curative. But what happens if a new treatment is introduced to practice before it has been clearly proven to be safe and effective? The use of an unproven, invasive therapy is not just associated with the risks of the intervention itself. Even if the treatment were harmless, there is the risk of unnecessary cost, inconvenience, and a missed opportunity for the patient to use existing therapies that are known to be effective. What’s more, if we need to play catch-up to try to establish an evidence base for a treatment that’s already in practice, we risk diverting scarce research resources towards a therapy that may not prove to be effective, simply because the genie is out of the bottle. <h2>Working towards a clearer answer</h2> Several more large <a href="https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000870954">clinical trials</a> are currently underway, and should increase our understanding of whether stem cell injections are safe and effective for knee osteoarthritis. Our review incorporates “<a href="https://www.cochrane.org/news/cochranes-pioneering-role-living-evidence">living evidence</a>”. This means we will continue to add the results of new trials as soon as they’re published, so the review is always up to date, and offers a comprehensive and trustworthy summary to help people with osteoarthritis and their health-care providers to make informed decisions. In the meantime, there are a number of <a href="https://www.racgp.org.au/clinical-resources/clinical-guidelines/key-racgp-guidelines/view-all-racgp-guidelines/knee-and-hip-osteoarthritis/summary-plain-language">evidence-based treatment options</a>. Non-drug treatments such as physiotherapy, regular exercise, maintaining a healthy weight, and cognitive behavioural therapy can be more effective than you think. Anti-inflammatory and pain medications can also play a supporting role. Importantly, it’s not inevitable that osteoarthritic joints get worse with time. So, even though <a href="https://aoanjrr.sahmri.com/background">joint replacement surgery</a> is often highly effective, it’s the last resort and fortunately, many people never need to take this step.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/253404/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> By <a href="https://theconversation.com/profiles/samuel-whittle-2357927">Samuel Whittle</a>, ANZMUSC Practitioner Fellow, <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/people-are-getting-costly-stem-cell-injections-for-knee-osteoarthritis-but-we-dont-know-if-they-work-253404">original article</a>. Image: Shutterstock </div>

Body

New study suggests shingles vaccine may lower dementia risk

A groundbreaking new study suggests that getting vaccinated against shingles could offer protection against dementia, adding to the growing evidence linking viral infections to cognitive decline. Shingles is a painful and debilitating condition that occurs in individuals who have previously had chickenpox. The varicella-zoster virus, responsible for both diseases, can lie dormant for years before reactivating as shingles. The latest research, published recently in Nature, analysed data from over 280,000 older adults in Wales. The findings reveal that individuals who received the original live-virus shingles vaccine were 20% less likely to develop dementia than those who were not vaccinated. The study was made possible by a unique public health policy in Wales, which provided an unusual opportunity to compare similar populations. On September 1, 2013, the vaccine was offered to individuals who were 79 years old on that date but not to those who had turned 80. This created two nearly identical groups, differing only in their eligibility for the vaccine, allowing researchers from Germany and Stanford University to examine its impact on dementia risk. “This study is essentially like a randomised controlled trial, which is the gold standard in research,” said Dr Pascal Geldsetzer, a Stanford University assistant professor of medicine and senior author of the study. Previous research has suggested an association between the newer Shingrix vaccine – which replaced the live-virus version in 2020 – and a lower risk of dementia, particularly in women. However, earlier studies were unable to fully account for differences between vaccinated and unvaccinated individuals, such as overall health status. Dr Allison Aiello, a professor of epidemiology at Columbia University’s Aging Centre, praised the design of the Welsh study. “It’s like having a control group compared to a treated group,” Aiello, who was not involved in the research, said. “The 20% reduction in dementia risk is a pretty strong effect, which aligns with other findings that suggest herpes viruses might influence dementia.” Scientists do not yet fully understand how the varicella-zoster virus increases dementia risk. One theory is that viral reactivation may contribute to the buildup of abnormal proteins associated with Alzheimer’s disease. Another possibility is that shingles reactivation might also trigger herpes simplex virus (HSV), which has previously been linked to dementia. Herpes viruses, including HSV-1 and HSV-2, can linger in the body indefinitely, often reactivating when the immune system weakens with age. These viruses can infiltrate the central nervous system, potentially leading to brain inflammation and neurodegenerative effects. A 2024 study found that among 70-year-olds without dementia at the outset, those diagnosed with herpes simplex were more than twice as likely to develop dementia over 15 years. While the new study offers compelling evidence, it is not a definitive randomised controlled trial, cautioned Dr William Schaffner, an infectious disease expert at Vanderbilt University Medical Centre. “It’s provocative, interesting and exciting,” he said. However, he noted that it would be unethical to randomly assign people to receive or forgo the vaccine. The US FDA may eventually review the accumulating research and consider updating the shingles vaccine label to reflect a possible dementia-protection benefit, Schaffner added. Even if such an update does not occur, doctors may use these findings to encourage more people over 50 to get vaccinated. “There are still many eligible people who haven’t received the vaccine,” Schaffner said. “If they hear that it might help prevent dementia, that could be the push they need.” Image: Supplied

Caring

Do any non-drug treatments help back pain? Here’s what the evidence says

<div class="theconversation-article-body"> Jason, a 42-year-old father of two, has been battling back pain for weeks. Scrolling through his phone, he sees ad after ad promising relief: chiropractic alignments, acupuncture, back braces, vibrating massage guns and herbal patches. His GP told him to “stay active”, but what does that even mean when every movement hurts? Jason wants to avoid strong painkillers and surgery, but with so many options (and opinions), it’s hard to know what works and what’s just marketing hype. If Jason’s experience sounds familiar, you’re not alone. Back pain is one of the most common reasons people visit a doctor. It can be challenging to manage, mainly due to widespread <a href="https://theconversation.com/having-good-posture-doesnt-prevent-back-pain-and-bad-posture-doesnt-cause-it-183732">misunderstandings</a> and the <a href="https://ebm.bmj.com/content/early/2025/03/02/bmjebm-2024-112974">overwhelming number</a> of ineffective and uncertain treatments promoted. We assessed the best available evidence of non-drug and non-surgical treatments to alleviate low back pain. <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD014691.pub2/full">Our review</a> – published today by the independent, international group the Cochrane Collaboration – includes 31 Cochrane systematic reviews, covering 97,000 people with back pain. It <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD014691.pub2/full">shows</a> bed rest doesn’t work for back pain. Some of the treatments that do work can depend on how long you’ve been in pain. <h2>Is back pain likely to be serious?</h2> There are different types of low back pain. It can: <ul> <li>be short-lived, lasting less than six weeks (acute back pain)</li> <li>linger for a bit longer, for six to twelve weeks (sub-acute)</li> <li>stick around for months and even years (chronic, defined as more than 12 weeks).</li> </ul> In <a href="https://www.thelancet.com/article/S0140-6736(16)30970-9/abstract">most cases</a> (90-95%), back pain is non-specific and cannot be reliably linked to a specific cause or underlying disease. This includes common structural changes seen in x-rays and MRIs of the spine. For this reason, imaging of the back is <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60172-0/abstract">only</a> recommended in rare situations – typically when there’s a clear suspicion of serious back issues, such as after physical trauma or when there is numbness or loss of sensation in the groin or legs. Many people expect to receive <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013815.pub2/full">painkillers</a> for their back pain or even surgery, but these are no longer the front-line treatment options due to limited benefits and the high risk of harm. International <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30489-6/fulltext">clinical guidelines</a> recommend people choose non-drug and non-surgical treatments to relieve their pain, improve function and reduce the distress commonly associated with back pain. So what works for different types of pain? Here’s what <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD014691.pub2/full">our review found</a> when researchers compared these treatments with standard care (the typical treatment patients usually receive) or no treatment. <h2>What helps for short-term back pain</h2> 1. Stay active – don’t rest in bed If your back pain is new, the best advice is also one of the simplest: keep moving despite the pain. Changing the way you move and use your body to protect it, or resting in bed, can seem like to right way to respond to pain – and may have even been recommended in the past. But we know know this excessive protective behaviour can make it harder to return to meaningful activities. This doesn’t mean pushing through pain or hitting the gym, but instead, trying to maintain your usual routines as much as possible. Evidence suggests that doing so won’t make your pain worse, and may improve it. 2. Multidisciplinary care, if pain lingers For pain lasting six to 12 weeks, multidisciplinary treatment is likely to reduce pain compared to standard care. This involves a coordinated team of doctors, physiotherapists and psychologists working together to address the many factors contributing to your back pain persisting: <ul> <li> neurophysiological influences refer to how your nervous system is currently processing pain. It can make you more sensitive to signals from movements, thoughts, feelings and environment </li> <li> psychological factors include how your thoughts, feelings and behaviours affect your pain system and, ultimately, the experience of pain you have </li> <li> occupational factors include the physical demands of your job and how well you can manage them, as well as aspects like low job satisfaction, all of which can contribute to ongoing pain. </li> </ul> <h2>What works for chronic back pain</h2> Once pain has been around for more than 12 weeks, it can become more difficult to treat. But relief is still possible. Exercise therapy Exercise – especially programs tailored to your needs and preferences – is likely to reduce pain and help you move better. This could include aerobic activity, strength training or Pilates-based movements. It doesn’t seem to matter what type of exercise you do – it matters more that you are consistent and have the right level of supervision, especially early on. Multidisciplinary treatment As with short-term pain, coordinated care involving a mix of physical, occupational and psychological approaches likely works better than usual care alone. Psychological therapies Psychological therapies for chronic pain include approaches to help people change thinking, feelings, behaviours and reactions that might sustain persistent pain. These approaches are likely to reduce pain, though they may not be as effective in improving physical function. Acupuncture Acupuncture probably reduces pain and improves how well you can function compared to placebo or no treatment. While some debate remains about how it works, the evidence suggests potential benefits for some people with chronic back pain. <h2>What doesn’t work or still raises uncertainty?</h2> The review found that many commonly advertised treatments still have uncertain benefits or probably do not benefit people with back pain. Spinal manipulation, for example, has uncertain benefits in acute and chronic back pain, and it likely does not improve how well you function if you have acute back pain. Traction, which involves stretching the spine using weights or pulleys, probably doesn’t help with chronic back pain. Despite its popularity in some circles, there’s little evidence that it works. There isn’t enough reliable data to determine whether advertised treatments – such back braces, vibrating massage guns and herbal patches – are effective. <h2>How can you use the findings?</h2> If you have back pain, start by considering how long you’ve had it. Then explore treatment options that research supports and discuss them with your GP, psychologist or physiotherapist. Your health provider should reassure you about the importance of gradually increasing your activity to resume meaningful work, social and life activities. They should also support you in making informed decisions about which treatments are most appropriate for you at this stage. <img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/253122/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" />By <a href="https://theconversation.com/profiles/rodrigo-rossi-nogueira-rizzo-1544189">Rodrigo Rossi Nogueira Rizzo</a>, Postdoctoral Research Fellow, <a href="https://theconversation.com/institutions/neuroscience-research-australia-976">Neuroscience Research Australia</a> and <a href="https://theconversation.com/profiles/aidan-cashin-2355450">Aidan Cashin</a>, NHMRC Emerging Leadership Fellow, <a href="https://theconversation.com/institutions/neuroscience-research-australia-976">Neuroscience Research Australia</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/do-any-non-drug-treatments-help-back-pain-heres-what-the-evidence-says-253122">original article</a>. Image: Shutterstock </div>

Body

Cricket world mourns passing of Ashes legend

Peter Lever, the former England fast bowler and a key member of the victorious 1970-71 Ashes side, has passed away at the age of 84. His former county, Lancashire, confirmed the news on Thursday. “We are deeply saddened by the news that Peter Lever has passed away, aged 84,” Lancashire posted on X. “Peter was inducted into our Hall of Fame last year after playing 301 First-Class matches between 1960 and 1976 — taking 796 wickets. Our thoughts are with his family and friends.” Lever played 17 Test matches and 10 One-Day Internationals for England, including the famous inaugural One Day International in 1971. Known for his aggressive pace and sharp movement, he left a lasting impact on the game. His England career began in 1970 against a Rest of the World XI at The Oval, where he took an impressive 7-83, dismissing cricketing greats such as Garry Sobers, Mushtaq Mohammad, Graeme Pollock, Clive Lloyd and Mike Procter. Although the match was later stripped of its Test status, his performance earned him an official England debut later that year in the Ashes series opener in Perth. Lever played a crucial role in England's 1970-71 Ashes triumph, which remains the last time Australia was whitewashed at home. He returned to Australia in 1975 and delivered a career-best performance, taking 6-38 in Melbourne. On the first day of that Test, he dismissed four of Australia’s top five batsmen for just two runs. Despite England securing an innings victory in that match, it was their only win in the six-Test series. However, one of the most defining moments of Lever's career came in 1975 during a Test match against New Zealand in Auckland. A bouncer he bowled struck debutant Ewen Chatfield on the unprotected left temple, causing him to collapse on the pitch. Chatfield's heart stopped, leading to fears that he had died, but he was revived through CPR by England physiotherapist Bernard Thomas. The traumatic incident deeply affected Lever, who later admitted that he contemplated retirement. Lever played only one more Test match after that, featuring in the second Ashes Test at Lord’s in 1975, where he took two wickets in a drawn game. He retired from first-class cricket the following year, concluding a distinguished career with Lancashire. Peter Lever will be remembered as a fierce competitor and a dedicated servant of English cricket. His contributions to the sport, particularly his role in England’s historic Ashes win, ensure his legacy will endure. Images: Daily Mail UK

Caring

King Charles admitted to hospital

Reports from Buckingham palace have revealed that King Charles has been forced to cancel a series of public engagements after being admitted to hospital due to side effects from his ongoing cancer treatment. The Palace released a statement on Thursday evening confirming that the 72-year-old monarch had “experienced temporary side effects that required a short period of observation in hospital” following his scheduled and ongoing medical treatment for cancer. The King has since returned to Clarence House, where he resides with Queen Camilla. “As a precautionary measure, acting on medical advice, tomorrow’s diary program will also be rescheduled,” the Palace added. Although the Palace did not specify the exact nature of the side effects, sources suggest such occurrences are not uncommon among cancer patients. A royal insider described the medical incident to The Daily Mail as a “most minor bump in a road that’s very much heading in the right direction”. However, in order to “protect and prioritise [his] continued very positive recovery”, King Charles has regretfully cancelled his planned engagements in Birmingham on Friday. The King was diagnosed with an undisclosed form of cancer in February last year and has been receiving outpatient treatment since then. Initially, he had to withdraw from public duties for several weeks but resumed engagements in April. Since then, he has travelled internationally – including a visit to Australia last October – and hosted numerous state visits while continuing his recovery. Last week, King Charles visited Ulster University’s Pharmacy and Pharmacology department in Northern Ireland to learn about their groundbreaking cancer research. During his visit, he shared words of encouragement with fellow cancer patients, quoting Winston Churchill’s famous phrase: “Keep buggering on.” Regarding the side effects of treatment, he remarked, “You just have to push on, don’t you?” While the specific type of cancer affecting the King has not been disclosed, reports suggest that it was caught at a very early stage. Royal sources remain optimistic about his recovery, and say his treatment is progressing positively. Image: Department of the Prime Minister and Cabinet/ Millie Pilkington

Caring

"Patrons yelled to stop": Comedy Festival rocked by death on opening night

Melbourne’s comedy scene was rocked by tragedy on the opening night of this year’s International Comedy Festival, as an attendee suffered a fatal medical episode mid-show, leading to the abrupt cancellation of the event. The distressing incident occurred during comedian Michael Hing’s performance at the Palais Theatre, where a man on the upper level of the venue suffered a medical emergency. Attendees quickly responded, providing CPR in the dark while Hing remained unaware of the unfolding crisis. “[It] would have been at least 15 mins worth before the show stopping, and [it] only stopped as patrons yelled to stop performing,” one audience member told The Daily Mail. Another witness expressed dismay over the handling of the situation, stating, “I can’t believe they [the organisers] didn’t communicate with backstage to halt the show, and that it took the public to yell out to the comedian to stop for something to happen.” The Melbourne International Comedy Festival addressed the incident in a statement posted on Instagram, confirming the show’s cancellation. “Melbourne International Comedy Festival regrets to confirm that there was a medical emergency while the Opening Night Allstars Supershow was taking place this evening at the Palais Theatre,” a festival spokesman said. “The show was stopped and cancelled. The Festival will be in touch with all ticket holders tomorrow.” Victoria Police later confirmed the man’s death. “Police will prepare a report for the Coroner following the death of a man in St Kilda on Wednesday, 26 March,” a spokesman said. “Emergency services were called to a theatre on Lower Esplanade about 9pm. A man, who is yet to be formally identified, died at the scene.” Health worker Andrea Bortoli, who was sitting in the upper level’s front row, described the distressing scene as people began leaving and it “became quite obvious that someone was getting CPR. It was just obviously really distressing, so we wanted to leave,” she told The Age. Eventually, the theatre lights were turned on, and patrons were informed that the show had been cancelled. The Allstars Gala is one of the most anticipated nights of the festival, bringing together some of the biggest names in comedy. This year’s event was hosted by Hing. As news of the tragedy spread, comedian Dave Hughes expressed his sympathies on social media, writing, “All performers thoughts are with the family affected”. Images: Palais Theatre / MichaelHing.com

Caring

"Game changer": Aussie women welcome new early-detection cancer test

Australian women will soon have access to a revolutionary blood test designed to aid in the early detection of breast cancer. The innovative test, known as BREASTEST plus™, was developed by BCAL Diagnostics and is set to complement traditional breast cancer screening methods such as mammograms and ultrasounds. BCAL Diagnostics chair Jayne Shaw <a href="https://7news.com.au/news/public-health/australian-first-blood-test-to-help-early-detection-of-breast-cancer-comes-to-sydney-before-nationwide-rollout-c-18153750" target="_blank" rel="noopener">revealed to 7NEWS</a> that the development of the test had taken 15 years, describing it as a "game changer" for women worldwide. “The breast test is a game changer for all women everywhere because it’s a blood test to detect breast cancer alongside other diagnostic tools like ultrasound and a mammogram,” Shaw said. She pointed out that a similar blood test for prostate cancer, which has been available since 1989, has significantly improved clinical outcomes for men. “Early diagnosis for all cancers will lead to improved survivability rates, and it was only inevitable that a blood test would be developed to diagnose breast cancer earlier,” she added. One of the major advantages of the new blood test is its ability to detect breast cancer in women with high breast density. Around 40-50% of Australian women undergoing screening have high breast density, which can obscure abnormalities on mammograms and make diagnosis more difficult. With the ability to identify breast cancer markers, the blood test will provide a valuable additional tool for detecting cancers that might otherwise go unnoticed. Breast Cancer Network Australia director Vicki Durston welcomed the new test, especially for its potential to improve the reporting of high breast density cases, where cancers are often missed. “Breast Cancer Network Australia has long been calling for the uplift in the breast density statement nationally to see standardised reporting across the country,” Durston said. She also noted that while high breast density is just one of many risk factors, the new test represents an innovative step forward in improving early detection and treatment. Breast cancer remains the most commonly diagnosed cancer among Australian women, accounting for approximately 28% of all new cancer cases. In 2024 alone, around 21,194 people were diagnosed with breast cancer in Australia, including 20,973 women and 221 men. However, survival rates have improved dramatically, with Australia’s peak breast cancer body reporting that the five-year survival rate has risen from 78% in 1994 to 92% in 2020, with many people living long and healthy lives beyond this period. While the test currently comes at an out-of-pocket cost, there is hope that the Australian government will eventually provide subsidies under Medicare to make it more accessible. The first tests will be available at the <a href="https://www.sydneybreastclinic.com.au/" target="_blank" rel="noopener">Sydney Breast Clinic</a> starting Thursday, followed by a rollout in Melbourne, with plans to expand nationwide by the end of the year. Images: Shutterstock / 7NEWS

Body

How long will you live? New evidence says it’s much more about your choices than your genes

<div class="theconversation-article-body"> One of the most enduring questions humans have is how long we’re going to live. With this comes the question of how much of our lifespan is shaped by our environment and choices, and how much is predetermined by our genes. A study recently published in the prestigious journal <a href="https://www.nature.com/articles/s41591-024-03483-9">Nature Medicine</a> has attempted for the first time to quantify the relative contributions of our environment and lifestyle versus our genetics in how we age and how long we live. The findings were striking, suggesting our environment and lifestyle play a much greater role than our genes in determining our longevity. <h2>What the researchers did</h2> This study used data from the <a href="https://www.ukbiobank.ac.uk/">UK Biobank</a>, a large database in the United Kingdom that contains in-depth health and lifestyle data from roughly 500,000 people. The data available include genetic information, medical records, imaging and information about lifestyle. A separate part of the study used data from a subset of more than 45,000 participants whose blood samples underwent something called “<a href="https://www.nature.com/articles/s41576-022-00511-7">proteomic profiling</a>”. Proteomic profiling is a relatively new technique that looks at how proteins in the body change over time to identify a person’s age at a molecular level. By using this method researchers were able to estimate how quickly an individual’s body was actually ageing. This is called their biological age, as opposed to their chronological age (or years lived). The researchers assessed 164 environmental exposures as well as participants’ genetic markers for disease. Environmental exposures included lifestyle choices (for example, smoking, physical activity), social factors (for example, living conditions, household income, employment status) and early life factors, such as body weight in childhood. They then looked for associations between genetics and environment and 22 major age-related diseases (such as coronary artery disease and type 2 diabetes), mortality and biological ageing (as determined by the proteomic profiling). These analyses allowed the researchers to estimate the relative contributions of environmental factors and genetics to ageing and dying prematurely. <h2>What did they find?</h2> When it came to disease-related mortality, as we would expect, age and sex explained a significant amount (about half) of the variation in how long people lived. The key finding, however, was environmental factors collectively accounted for around 17% of the variation in lifespan, while genetic factors contributed less than 2%. This finding comes down very clearly on the nurture side in the “nature versus nurture” debate. It suggests environmental factors influence health and longevity to a far greater extent than genetics. Not unexpectedly, the study showed a different mix of environmental and genetic influences for different diseases. Environmental factors had the greatest impact on lung, heart and liver disease, while genetics played the biggest role in determining a person’s risk of breast, ovarian and prostate cancers, and dementia. The environmental factors that had the most influence on earlier death and biological ageing included smoking, socioeconomic status, physical activity levels and living conditions. Interestingly, being taller at age ten was found to be associated with a shorter lifespan. Although this may seem surprising, and the reasons are not entirely clear, this aligns with <a href="https://www.sciencedaily.com/releases/2014/05/140509110756.htm">previous research</a> finding taller people are more likely to die earlier. Carrying more weight at age ten and maternal smoking (if your mother smoked in late pregnancy or when you were a newborn) were also found to shorten lifespan. Probably the most surprising finding in this study was a lack of association between diet and markers of biological ageing, as determined by the proteomic profiling. This flies in the face of the extensive body of evidence showing the crucial role of <a href="https://www.nature.com/articles/s43016-023-00868-w">dietary patterns</a> in chronic disease risk and longevity. But there are a number of plausible explanations for this. The first could be a lack of statistical power in the part of the study looking at biological ageing. That is, the number of people studied may have been too small to allow the researchers to see the true impact of diet on ageing. Second, the dietary data in this study, which was self-reported and only measured at one time point, is likely to have been of relatively poor quality, limiting the researchers’ ability to see associations. And third, as the relationship between diet and longevity is likely to be complex, disentangling dietary effects from other lifestyle factors may be difficult. So despite this finding, it’s still safe to say the food we eat is one of the most important pillars of health and longevity. <h2>What other limitations do we need to consider?</h2> Key exposures (such as diet) in this study were only measured at a single point in time, and not tracked over time, introducing potential errors into the results. Also, as this was an observational study, we can’t assume associations found represent causal relationships. For example, just because living with a partner correlated with a longer lifespan, it doesn’t mean this caused a person to live longer. There may be other factors which explain this association. Finally, it’s possible this study may have underestimated the role of genetics in longevity. It’s important to recognise genetics and environment don’t operate in isolation. Rather, health outcomes are shaped by their interplay, and this study may not have fully captured the complexity of these interactions. <h2>The future is (largely) in your hands</h2> It’s worth noting there were a number of factors such as household income, home ownership and employment status associated with diseases of ageing in this study that are not necessarily within a person’s control. This highlights the crucial role of addressing the social determinants of health to ensure everyone has the best possible chance of living a long and healthy life. At the same time, the results offer an empowering message that longevity is largely shaped by the choices we make. This is great news, unless you have good genes and were hoping they would do the heavy lifting. Ultimately, the results of this study reinforce the notion that while we may inherit certain genetic risks, how we eat, move and engage with the world seems to be more important in determining how healthy we are and how long we live.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/251054/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/hassan-vally-202904">Hassan Vally</a>, Associate Professor, Epidemiology, <a href="https://theconversation.com/institutions/deakin-university-757">Deakin University</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-long-will-you-live-new-evidence-says-its-much-more-about-your-choices-than-your-genes-251054">original article</a>. Image: Shutterstock </div>

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